期刊文献+

乳腺非典型微腺体腺病临床病理观察

Atypical microglandular adenosis of breast: a case report and review of literature
收藏 分享 导出
摘要 目的 分析乳腺非典型微腺体腺病(MGA)的临床及病理组织学特征.方法 应用光镜观察及免疫组化染色对1例乳腺非典型MGA进行临床病理分析,同时复习相关文献.结果 患者女性,49岁.右侧乳腺浸润性小叶癌切除4年,发现左乳肿物4年.左乳乳腺纤维组织和脂肪组织中可见弥漫增生的腺管及腺泡成分,大部分腺体呈圆形,细胞呈单层立方形,腺腔开放,细胞胞质略透明或嗜酸性,部分腺体腺腔内可见嗜酸性分泌物.局灶间质纤维化,部分区域小腺管结构复杂,细胞增生,腺体融合,细胞出现轻~中度异型性.免疫组化:小腺体S-100强(+),CK5/6、p63、SMA、calponin、EMA、ER、PR、c-erbB-2和p53(-),cathepsin D(+),Laminin显示完整基底膜围绕腺体.结论 MGA病例少见,形态学及免疫组化相结合有助于诊断与鉴别诊断. Objective To analyze the clinical and pathologic features of atypical microglandular adenosis (MGA) of the breast. Methods A case of MGA of the breast was studied by microscopy and immunohistochemistry, with review of related literature. Results The patient was a 49-year-old woman, with a history of resected invasive lobular carcinoma of her right breast 4 years ago, and a mass of her left breast was also found at that time. Histologically, the tumor of her left breast was composed of small round glands and acini infiltrating fibrous septa or fatty mammary stroma. Most of the glands were open and lined by a single layer of cuboidal epithelial cells, with slight clear or eosinophilic cytoplasm and luminal eosinophilic secretions in some glands. Focal fibrosis was present. In some areas, the glandular structures were complex, the proliferative cells showed mild to moderate atypia, with some glands fused. Immunostaining showed that the glands were S-100+ (strong), CK5/6-, p63-, SMA-, calponin-, CK+, EMA-, ER-, PR-,e-erbB-2-, cathepsinD+, and p53 - , and the intact basement membrane were demonstrated by laminin. Conclusions MGA is a rare lesion. The combination of morphology and immunohistochenmistry is useful for the diagnosis and differential diagnosis.
作者 陈定宝 沈丹华 王颖 阚秀 CHEN Ding-bao, SHEN Dan-hua, WANG Ying, KAN Xiu (Department of Pathology, Peking University People's Hospital, Beijing 100044, China)
出处 《诊断病理学杂志》 CSCD 北大核心 2014年第8期495-497,共3页 Chinese Journal of Diagnostic Pathology
关键词 乳腺 微腺体腺病 鉴别诊断 Breast Microglandular adenosis Differential diagnosis
  • 相关文献

参考文献7

  • 1McDivitt RW,Stewart FW,Berg GW.Tumors of the breast.Atlas of tumor pathology,Armed forces institute of pathology[M].Second series.DC:Washington,1968.91. 被引量:1
  • 2Lakhani SR,Ellis LO,Schnitt SJ,et al.WHO classification of tumours of the breast[M].Lyon:IARC Pressn (4th eds.),2012.113-114. 被引量:1
  • 3Paul Peter Rosen MD.Rosen's breast pathology[M].3rd edition,Philadelphia:Lippincott Williams and Wilkins,2008,161-186. 被引量:1
  • 4水若鸿,成宇帆,杨文涛.起源于乳腺微腺体腺病的浸润性癌3例临床病理学观察[J].中华病理学杂志,2011,40(7):471-474. 被引量:4
  • 5Khalifeh I,Albarracin C,Wu Y,et al.Clinical,histopathologic,and biologic/molecular features of microglandular adenosis with transition into in-situ and invasive carcinoma[J].Mod Pathol,2007,20(suppl.2):38A. 被引量:1
  • 6Khalifeh IM,Albarracin C,Diaz LK.Clinical,histopathologic,and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma[J].Am J Surg Pathol,2008,32(4):544-552. 被引量:1
  • 7Shin SJ,Simpson PT,Da Silva L,et al.Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma[J].Am J Surg Pathol,2009,33 (4):496-504. 被引量:1

二级参考文献16

  • 1Rosen PP. Adenosis and microglandular adenosis//Rosen PP. Rosen's breast pathology. 3rd ed. Philadephia: Lippincott Williams and Wilkins, 2009 : 175-186. 被引量:1
  • 2Rosenblum MK, Purrazzella R, Rosen PP. Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. Am J Surg Pathol, 1986, 10(4) : 237-245. 被引量:1
  • 3Tavassoli FA, Norris HJ. Microglandular- - adenosis of the breast. A clinicopathologic study of 11 cases with uhrastructural observations. Am J Surg Pathol, 1983, 7(8) : 731-737. 被引量:1
  • 4James BA, Cranor ML, Rosen PP. Carcinoma of the breast arising in microglandular adenosis. Am J Clin Pathol, 1993, 100 (5) : 507 -513. 被引量:1
  • 5Koeing C, Dadmanesh F, Bratthauer GL, et al. Carcinoma arising in microglandular adenosis: an immunohistochemical analysis of 20 intraepithelial and invasive neoplasms. Int J Surg Pathol, 2000, 8 (4) : 303-315. 被引量:1
  • 6Wolff AC, Hammond ME, Schwartz JN, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med, 2007, 131 ( 1 ) : 18.43. 被引量:1
  • 7McDivitt RW, Stewart FW, Berg GW. Tumors of the breast// Hartman WH. Atlas of tumor pathology. 2nd ed. Washington DC : Armed Forces Institute of Pathology, 1968: 91. 被引量:1
  • 8Clement PB, Azzopardi JG. Microglandular adenosis of the breast : a lesion simulating tubular carcinoma. Histopathology, 1983, 7 (2) : 169-180. 被引量:1
  • 9Rosen PP. Micmglandular adenosis. A benign lesion simulating invasive mammary carcinoma. Am J Surg Pathol, 1983, 7 ( 2 ) : 137-144. 被引量:1
  • 10Tavassoli FA, Bratthauer GL. Immunohistochemical profile and differential diagnosis of microglandular adenosis. Mod Pathol, 1993, 6(3) : 318-322. 被引量:1

共引文献3

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈