期刊文献+

功能性鼻内镜鼻窦手术后换药应用布地奈德混悬液的效果分析 被引量:8

Budesonide used after functional endoscopic sinus surgery
收藏 分享 导出
摘要 目的探讨在慢性鼻-鼻窦炎患者术后应用布地奈德混悬液(普米克令舒)的效果。方法分析280例慢性鼻-鼻窦炎行鼻内镜手术的患者,随机分为2组,A组常规换药,术后常规使用布地奈德鼻喷剂喷鼻;B组对有囊泡及水肿明显者在术后换药过程中清理后予以明胶海绵浸润布地奈德混悬液置于囊泡及水肿部位,每周1~2次,观察术后1个月、3个月及6个月的疗效,包括VAS视觉量表主观评估及鼻内镜Lund-Kennedy客观评估。结果 A、B组术后1、3、6个月VAS评分分别为4.48±1.33,2.16±0.81,2.04±0.96;3.85±1.09,1.90±0.88,1.93±0.74。A、B组术后1、3、6个月Lund-Kennedy评分分别为11.44±1.73,4.51±1.05,3.94±0.86;6.82±2.08,4.26±1.17,2.17±0.79。两组患者的VAS评分在术后三个时间点差异均有统计学意义(P〈0.05);术后3个月、6个月与术后1个月比较,差异有统计学意义(P〈0.05);而术后3个月与术后6个月相比,差异无统计学意义。两组间Lund-Kennedy客观评估比较,在术后1个月和6个月两个时间点差异有统计学意义(P〈0.05),而在术后3个月,两组比较差异无统计学意义;术后3个月、6个月与术后1个月比较,差异有统计学意义(P〈0.05);而术后3个月与术后6个月相比,A组在两个时间点差异有统计学意义,B组在两个时间点差异无统计学意义。结论慢性鼻-鼻窦炎鼻内镜术后应用布地奈德混悬液能更好地减少术后囊泡形成、减轻水肿,促进黏膜上皮化。 Objective To investigate the effect of Budesonide after functional endoscopic sinus surgery( FESS) for chronic nasal-sinusitis. Methods A total of 280 cases of chronic nasal-sinusitis( CRS) which underwent FESS were randomly divided into two groups: A group was regular dressing group with Budesonide nasal spray; B group was put gelatin sponge with Budesonide infiltration at vesicles and edema place in the post-operative dressing process,1-2 times a week. Then we adopted VAS visual assessment and Lund-Kennedy assessment to assess the dressing effect after one,three and six months of FESS. Results The VAS scores and Lund-Kennedy scores of A and B groups at 1,3 and 6months were 4. 48 ± 1. 33,2. 16 ± 0. 81,2. 04 ± 0. 96; 3. 85 ± 1. 09,1. 90 ± 0. 88,1. 93 ± 0. 74 and 11. 44 ± 1. 73,4. 51 ± 1. 05,3. 94 ± 0. 86; 6. 82 ± 2. 08,4. 26 ± 1. 17,2. 17 ± 0. 79. The VAS score at the three time points was statistically significant between the two groups( P〈0. 05); The VAS score of the 3 and 6 months was statistically significant with that of 1 month( P〈0. 05); while it was not statistically significant between the 3 and 6 months. The Lund-Kennedy score at 1 and 6 months was statistically significant between the two groups( P〈0. 05); The Lund-Kennedy score at 3 and 6 months was statistically significant( P〈0. 05); while between 3 months and 6 months,it was statistically significant in the A group,but not in the B group. Conclusion Budesonide after FESS of CRS can better reduce vesicle formation,mitigate edema and promote mucosal epithelium.
作者 张卫拾 高刚 钱茂华 季超 ZHANG Wei-shi,GAO Gang,QIAN Mao-hua,JI Chao( Department of Otolaryngology & Head and Neck Surgery, Nantong First People's Hospital, Nantong 226001, Jiangsu, China)
出处 《山东大学耳鼻喉眼学报》 CAS 2014年第4期43-45,共3页 Journal of Otolaryngology and Ophthalmology of Shandong University
关键词 鼻窦炎 慢性 鼻内镜外科手术 布地奈德 Nasal-sinusitis chronic Functional endoscopic sinus surgery Budesonide suspension
作者简介 张卫拾。E—mail:122053535@qq.com 通讯作者:高刚。E-mail:ggao200801@163.com
  • 相关文献

参考文献8

  • 1许庚,李源,谢民强,史剑波,李华斌.功能性内窥镜鼻窦手术后术腔粘膜转归阶段的划分及处理原则[J].中华耳鼻咽喉科杂志,1999,34(5):302-305. 被引量:609
  • 2Lim M,Lew-Gor S, Darby Y,et al. The relationship be-tween subjective assessment instruments in chronic rhino-sinusitis[ J]. Rhinology,2007, 45(1) : 144-147. 被引量:1
  • 3Lund V J,Kennedy D W. Staging for rhinosinusitis[ J].Otolaryngol Head Neck Surg, 1997,117(3 pt 2) : S35-S40. 被引量:1
  • 4Berlucchi M, Castelnuovo P, Vincenzi A,et al. Endo-scopic outcomes of resorbable nasal packing after func-tional endoscopic sinus surgery ; a multicenter prospectiverandomized controlled study[ J]. Eur Arch Otorhinolaryn-gol, 2009, 266(6) :83945. 被引量:1
  • 5Wee J H,Lee C H,Rhee C S,et al. Comparison be-tween Gelfoam packing and no packing after endoscopicsinus surgery in the same patients[ J]. Eur Arch Otorhino-laryngol, 2012, 269(3):897-903. 被引量:1
  • 6许庚.非变应性持续性鼻炎(慢性鼻炎)局部糖皮质激素治疗新概念[J].临床耳鼻咽喉头颈外科杂志,2007,21(14):636-638. 被引量:35
  • 7Albertien A C, Aukema M D, Paul G H, et al. Treat-ment of nasal polyposis and chronic rhinosinusitis wit hfluticasone propionate nasal drops reduces need for sinussurgery [J]. Allergy Clin Immunol, 2005, 115(5):1017-1023. 被引量:1
  • 8Palmer J N, Kennedy D W. Medical management infunctional endoscopic sinus surgery failures [ J ]. CurtOpin Otolaryngol Head Neck Surg, 2003, 11(1) :6-12. 被引量:1

二级参考文献16

  • 1中华医学会耳鼻咽喉科学会,中华耳鼻咽喉科杂志,1998年,33卷,134页 被引量:1
  • 2韩德民,中华耳鼻咽喉科杂志,1996年,31卷,358页 被引量:1
  • 3许庚,内窥镜鼻窦外科学,1994年,123页 被引量:1
  • 4BACHERT C.Persistent rhinitis-allergic or nonallergic[J]? Allergy,2004,59:11-15. 被引量:1
  • 5SPECTOR S L,BERNSTEIN I L,LI J T,et al.Parameters for the diagnosis and management of sinusitis[J].J Allergy Clin Immunol,1998,102:S107-44. 被引量:1
  • 6FIREMAN P.Rhinitis and asthma connection:management of coexisting upper airway allergic diseases and asthma[J].Allergy Asthma Proc,2000,21:45-54. 被引量:1
  • 7OHASHI Y,NAKAI Y,IKEOKA H,et al.Regeneration of nasal mucosa following mechanical injury[J].Acta Otolaryngol,1991,:193-201. 被引量:1
  • 8MALONE D C,LAWSON K A,SMITH D H,et al.A cost of illness study of allergic rhinitis in the Unit ed States[J].J Allergy Clin Immunol,1997,99:22 -27. 被引量:1
  • 9YOUNG T,FINN L,KIM H.For the University of Wisconsin Sleep and Respiratory Research Group.Nasal obstruction as a risk factor for sleep-disordered breathing[J].J Allergy Clin Immunol,1997,99:S757-762. 被引量:1
  • 10CRAIG T J,TEETS S,LENMAN E B,et al.Nasal congestion secondaryto allergic rhinitis as a cause of sleep disturbance and daytime fatigue and the response to topical nasal corticosteroids[J].J Allergy Clin Immunol,1998,101:633-637. 被引量:1

共引文献638

同被引文献66

  • 1突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41(8):569-569. 被引量:753
  • 2DISPENZA F,DE STEFANO A,COSTANTINO C,et al.Sudden sensorineural hearing loss:results of intratympanic steroids as salvage treatment[J].Am J Otolaryngol,2013,34:296-300. 被引量:1
  • 3CHANDRASEKHAR S S,RUBINSTEIN R Y,KWARTLER J A,et al.Dexamethasone pharmacokinetics in the inner ear:comparison of route of administration and use of facilitating agents[J].Otolaryngol Head Neck Surg,2000,122:521-528. 被引量:1
  • 4YANG F,ZHAO Y,AN P,et al.Longitudinal results of intratympanic injection of budesonide for otitis media with effusion in children over 12years and adults[J].Otol Neurotol,2014,35:629-634. 被引量:1
  • 5STOKROOS R J,ALBERS F W,SCHIRM J.The etiology of idiopathic sudden sensorineural hearing loss.Experimental herpes simplex virus infection of the inner ear[J].Am J Otol,1998,19:447-452. 被引量:1
  • 6SEGGAS I,KOLTSIDOPOULOS P,BIBAS A,et al.Intratympanic steroid therapy for sudden hearing loss:a review of the literature[J].Otol Neurotol,2011,32:29-35. 被引量:1
  • 7VLASTARAKOS P V,PAPACHARALAMPOUS G,MARAGOUDAKIS P,et al.Are intra-tympanically administered steroids effective in patients with sudden deafness?Implications for current clinical practice[J].Eur Arch Otorhinolaryngol,2012,269:363-380. 被引量:1
  • 8FERRI E,FRISINA A,FASSON A C,et al.Intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss after failure of intravenous therapy[J].ISRN Otolaryngol,2012,2012:647271. 被引量:1
  • 9WU H P,CHOU Y F,YU S H,et al.Intratympanic steroid injections as a salvage treatment for sudden sensorineural hearing loss:a randomized,doubleblind,placebo-controlled study[J].Otol Neurotol,2011,32:774-779. 被引量:1
  • 10KAKEHATA S,SASAKI A,FUTAI K,et al.Daily short-term intratympanic dexamethasone treatment alone as an initial or salvage treatment for idiopathic sudden sensorineural hearing loss[J].Audiol Neurootol,2011,16:191-197. 被引量:1

引证文献8

二级引证文献6

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈