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老年恶性肿瘤患者血浆纤维蛋白单体和D-二聚体的测定及临床意义 预览 被引量:5

Determination of plasma fibrin monomer and Dˉdimer in gerontal patients with malignant tumor and its clinical significance
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摘要 目的:探讨血浆纤维蛋白单体(FM)和 D-二聚体(D-D)在老年恶性肿瘤患者中的诊断及临床应用。方法采用免疫比浊法分别定量测定了29例老年恶性肿瘤患者、20例非老年恶性肿瘤患者、24例老年健康者、30例非老年健康体检者的 FM 和D-D。结果肿瘤患者的 FM 和 D-D 的检测结果较健康体检者明显增高(P <0.05)。老年恶性肿瘤患者与非老年恶性肿瘤患者之间 FM 和 D-D 差异无统计学意义(P >0.05)。老年健康体检者的 FM 和非老年健康体检者的 FM 比较,差异无统计学意义(P>0.05)。但是老年健康体检者和非老年健康体检者的 D-D 差异有统计学意义(P <0.05)。结论 FM 和 D-D 都可以作为肿瘤患者诊断肿瘤性血栓的指标。D-D 对老年恶性肿瘤患者诊断肿瘤性血栓是没有意义的,在诊断老年恶性肿瘤患者肿瘤性血栓时,须联合 FM 和 D-D。 Objective To explore the diagnosis and clinical application of fibrin monomer(FM)and D-dimer(D-D)in gerontal pa-tients with malignancy tumor.Methods FM and D-D were detected in 29 gerontal patients with malignant tumor,20 gerontal pa-tients with non-malignant tumor,24 gerontal healthy controls and 30 non-gerontal healthy controls by immunoturbidimetry(ITM). Results The testing results of FM and D-D in the tumor patients were significantly higher than those in the healthy controls(P 〈0.05).There was no statistical difference in FM and D-D between the gerontal patients with malignant tumor and the gerontal pa-tients with non malignant tumor(P 〉0.05).There was no statistical difference in FM between the gerontal healthy examination and non-gerontal healthy examination(P 〉0.05).There was statistical difference in D-D between the gerontal healthy examination and non-gerontal healthy examination (P 〈 0.05 ).Conclusion FM and D-D could be used as the indicators for diagnosing tumor thrombus in gerontal patients with tumor.However,D-D has meaningless in diagnosing tumor thrombus.In the diagnosis of tumor thrombus in gerontal patients with malignant tumor,the combination of FM and D-D should be needed.
作者 谢国丽 张朝明 江泽友 Xie Guoli, Zhang Chaoming, Jiang Zeyou (College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chegndu, Sichuan 610072, China ; Department of Clinical Laboratory ,Affiliated Hospital of Chengdu University of Traditional Chengdu Medicine, Chegndu, Sichuan 610072, China)
出处 《国际检验医学杂志》 CAS 2014年第24期3334-3335,共2页 International Journal of Laboratory Medicine
关键词 血浆纤维蛋白单体 D-二聚体 恶性肿瘤 肿瘤性血栓 plasma fibrin monomer D-dimer malignant tumor tumor thrombus
作者简介 谢国丽,女,在读硕士研究生,主要从事临床生化检验研究。 通讯作者,E—mail:18981885705@163.com。
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