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复合抗菌肽对断奶仔猪生长性能及血清细胞因子含量的影响 预览 被引量:12

Effects of Complex Antibacterial Peptide on Growth Performance and Serum Cytokine Contents of Weaned Piglets
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摘要 本试验旨在研究饲粮复合抗菌肽水平对断奶仔猪生长性能及血清细胞因子含量的影响。将90头26日龄的健康杜×长×大三元杂交断奶仔猪按体重相近、公母各占1/2的原则随机分成5组,每组3个重复,每个重复6头。对照组饲喂基础饲粮,试验组分别在基础饲粮中添加400 mg/kg黄芪多糖,250、500和1 000 mg/kg的复合抗菌肽,试验期28 d。结果表明:1)与对照组相比,饲粮中添加250、500和1 000 mg/kg复合抗菌肽和400 mg/kg黄芪多糖均能提高断奶仔猪的平均日增重,降低料重比,且1 000 mg/kg复合抗菌肽的效果均优于400 mg/kg黄芪多糖。2)与对照组相比,饲粮中添加250 mg/kg复合抗菌肽显著或极显著提高断奶仔猪血清白介素-2(IL-2)(46和53日龄)、白介素-4(IL-4)(39、46和53日龄)、白介素-6(IL-6)(39、46和53日龄)、干扰素-γ(IFN-γ)(32、39、46和53日龄)和肿瘤坏死因子-α(TNF-α)(53日龄)的含量(P〈0.05或P〈0.01);在整个试验期间,除饲粮中添加500 mg/kg复合抗菌肽对32日龄断奶仔猪血清IL-2、IL-4含量和饲粮中添加1 000 mg/kg复合抗菌肽对32日龄断奶仔猪血清IL-4含量无显著影响(P〉0.05)外,饲粮中添加500和1 000 mg/kg复合抗菌肽均显著或极显著提高断奶仔猪血清中IL-2、IL-4、IL-6、IFN-γ和TNF-α含量(P〈0.05或P〈0.01),且效果均优于400 mg/kg黄芪多糖。由此可见,饲粮中添加复合抗菌肽能够提高断奶仔猪的生长性能及免疫功能,以添加量为1 000 mg/kg时效果较好。 This experiment was conducted to investigate the effects of complex antibacterial peptide on growth performance and serum cytokine contents of weaned piglets. Ninety 26-day-old healthy crossed weaned piglets ( Duroc×Landrace×Yorkshire) were randomly divided into 5 groups with 3 replicates per group and 6 piglets per replicate according to the similar body weight, and half male and half female. The piglets in control group were fed a basal diet and those in experimental groups were fed the basal diet supplemented with 400 mg/kg Astragalus polysaccharide, and 250, 500, 1 000 mg/kg complex antibacterial peptide, respectively. The ex-periment period was 28 days. The results showed as follows:1) compared with the control group, the supple-mentation of 250, 500 and 1 000 mg/kg complex antibacterial peptide and 400 mg/kg Astragalus polysaccha-ride could improve the average daily gain and decrease the ratio of feed to gain of weaned piglets, and the effects of the 1 000 mg/kg complex antibacterial peptide were better than those of 400 mg/kg Astragalus poly-saccharide. 2) Compared with the control group, the supplementation of 250 mg/kg complex antibacterial pep-tide could significantly improve the contents of serum interleukin (IL)-2 (46 and 53 days of age), IL-4 (39, 46 and 53 days of age), IL-6 (39, 46 and 53 days of age), interferon-γ(IFN-γ) (32, 39, 46 and 53 days of age) and tumor necrosis factor-α (TNF-α) (53 days of age) (P〈0.05 or P〈0.01). During the entire ex-perimental period, except the supplementation of 500 mg/kg complex antibacterial peptide had no significant effects on serum IL-2 and IL-4 contents of weaned piglets at the age of 32 days and the supplementation of 1 000 mg/kg complex antibacterial peptide had no significant effects on serum IL-4 content of weaned piglets at the age of 32 days ( P〉0.05) , the contents of serum IL-2, IL-4, IL-6, IFN-γand TNF-αwere significantly improved by the supplementation of 500 and 1 000 mg/kg complex antib
作者 袁威 任志华 邓又天 邓慧丹 邓俊良 胡洋 YUAN Wei, REN Zhihua, DENG Youtian, DENG Huidan, DENG Junliang, HU Yang (1. Key Laboratory of Animal Diseases and Environmental Hazard of Sichuan Province, Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary, Sichuan Agricultural University, Ya' an 625014, China; 2. Rota Bioengineering Co., Ltd., Chengdu 610000, China)
出处 《动物营养学报》 CAS CSCD 北大核心 2015年第3期885-892,共8页 Acta Zoonutrimenta Sinica
基金 “长江学者和创新团队发展计划”创新团队项目(IRT0848)
关键词 复合抗菌肽 断奶仔猪 生长性能 细胞因子 complex antibacterial peptide weaned piglets growth performance cytokines
作者简介 袁威(1990-),男,重庆奉节人,硕士研究生,研究方向为中西兽医与临床。E—mail:yw20091414@163.com 通信作者:邓俊良,教授,博士生导师,E—mail:dengj1213@126.com
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