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年轻女性乳腺癌163例的临床病理特点及分子分型 预览 被引量:13

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摘要 目的:分析年轻女性乳腺癌的临床病理特征及分子分型,为年轻女性乳腺癌临床诊治提供经验。方法回顾性分析确诊并行手术治疗的163例年轻(≤35岁)女性乳腺癌(年轻组)的临床病理资料、相关免疫组化指标及分子分型,并与同期诊断的94例老年(≥60岁)女性乳腺癌(老年组)进行对比分析。结果年轻女性乳腺癌病理类型以浸润性导管癌为主,占80.4%(131/163)。与老年组比较,其组织学分级(Ⅱ、Ⅲ级)更高、ER表达水平则更低;LuminalA型所占比例较老年组低,而三阴性型较老年组高,差异有统计学意义(P<0.05)。而两组间病理类型、肿瘤大小、腋窝淋巴结转移率、病理分期、PR及P53表达水平的差异均无统计学意义(P>0.05)。结论年轻女性乳腺癌有特殊的临床病理特征,其组织学分级高,而ER表达水平低,三阴性型所占比例高,而LuminalA比例低,其恶性程度更高,临床医生需依据病理学指标进行预后风险评估和制定个体化治疗策略。
出处 《广东医学》 CAS 北大核心 2015年第4期554-556,共3页 Guangdong Medical Journal
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