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乙型肝炎病毒感染标志物的检测现状和思考 被引量:30

Markers of hepatitis B virus infection: current application and prospect
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摘要 慢性乙型肝炎的病程可从非活动性携带者到进展性慢性肝炎(CHB)、肝硬化、肝癌。我国现有慢性HBV感染者约9300万例,其中慢性乙肝患者约2000万,原发性肝癌是我国男性的第二大肿瘤相关死因。高发病率、高致死率的肝硬化及肝癌已经成为影响国民健康和生活质量的重要因素并成为社会有限医疗资源的沉重负担。本文重点从病毒抗原和核酸两方面阐述目前HBV感染标志物检测的临床应用现状及相关进展,并提出作为检验医师应重视HBV标志物的合理应用和诠释,积极参与临床诊治,为提高我国乙肝的临床诊治水平做出检验人的贡献。(中华检验医学杂志,2015,38:145-147) The natural history of chronic HBV infection is diverse and variable, ranging from inactive carriers to progressive chronic hepatitis B (CHB), cirrhosis and hepatocelluar carcinoma. It is estimated that 93 million people are chronically infected with HBV and 20 million cases suffering from chronic hepatitis B in China. Hepatocelluar carcinoma has been the second leading cause of death for male in China. Liver cirrhosis and HCC which have high mortality and morbidity have become the heavy burden for the limited medication resource of China. Here the current clinical applications and consensus progression based on antigen and nuclear acid detection were acknowledged. The reasonable application as well as appropriate clinical interpretation are emphasized indicating that laboratory medicine practitioners should be more actively involved in clinical diagnosis and treatment. More efforts and contributions should be made by the laboratory medicine practitioner for optimizing clinical management of HBV-related diseases in future. (Chin J Lab Med,2015,38:145-147)
作者 高春芳 吴孟超 Markers of hepatitis B virus infection: current application and prospect Gao Chunfang, Wu Mengchao. Department of Laboratory Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Corresponding author: C, ao Chunfang , Email : gaocfl l l S @ 163. corn
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2015年第3期145-147,共3页 Chinese Journal of Laboratory Medicine
基金 “十二五”重大专项(2012zxl0002016001003)
关键词 乙型肝炎 慢性 生物学标记 乙型肝炎表面抗原 乙型肝炎E抗原 乙型肝炎核心抗原 Hepatitis B, chronic Biological markers Hepatitis B surface antigens HepatitisB e antigens Hepatitis B core ntigens
作者简介 高春芳,电子信箱:gaocflll5@163.com
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参考文献16

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