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利培酮与氟哌啶醇治疗老年帕金森伴精神障碍的疗效对比分析 被引量:8

Comparative analysis of therapeutic effect of risperidone and haloperidol in the treatment of senile Parkinson with mental disorder
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摘要 目的探讨利培酮与氟哌啶醇治疗老年帕金森伴精神障碍的临床疗效。方法将我院2010年4月至2013年12月期间收治的PD合并精神障碍的老年患者102例随机分为研究组51例和对照组51例,两组患者调整对抗帕金森药物后,研究组患者给予利培酮片,对照组给予氟哌啶醇进行治疗,治疗前及治疗4周后对患者进行UPDRS、阴性阳性症状评定量表(PANSS)、汉米顿抑郁量表(HAMD)及微型精神状况评定量表(MMSE)量表评分,同时记录两组患者的不良反应发生情况。结果研究组患者经过治疗各项指标均有显著好转,同时治疗后研究组患者的PANSS评分明显低于对照组患者,MMSE评分显著高于对照组患者,差异均具有统计学意义(P〈0.05),同时对照组患者的UPDRS、PANSS、HAMD显著降低,而MMSE评分明显升高,差异均具有统计学意义(P〈0.05);而各项不良发应发生情况比较无显著性差异(P〉0.05)。结论利培酮与氟哌啶醇治疗老年帕金森伴精神障碍均具有较好的治疗效果,安全性高,但是利培酮对患者的精神障碍症状的改善显更加显著,同时对老年患者的认知功能无影响。 Objective To investigate the clinical effect of risperidone and haloperidol treatment senile Parkinson with mental disorder. Methods The combined with mental disorders in our hospital from 2010 April to 2013 December during the PD of 102 cases of elderly patients were randomly divided into study group 51 cases and control group 51 cases,the patients in the two groups after adjustment against Parkinson drugs,patients in study group were given Risperidone Tablets,patients in the control group received the treatment of haloperidol tablets,before treatment and after 4 weeks of treatment on patients with UPDRS,PANSS,HAMD and MMSE scale score,and recorded the occurrence of adverse reactions of two groups of patients. Results Study group patients after treatment of various indicators improved significantly,while the study group patients after treatment,PANSS score significantly lower than control group patients,MMSE score significantly higher than control group patients,the difference was statistically significant( P 〈 0. 05),while control group patients UPDRS,PANSS,HAMD decreased,and MMSE score increased significantly,the differences were with statistical significance( P 〈 0. 05); and the incidence of adverse reaction and there is no significant difference( P 〉 0. 05). Conclusion Risperidone and haloperidol in the treatment of complicated with mental disorder have better treatment effect of senile Parkinson,high safety,but the improvement of symptoms in patients with mental disorders risperidone significantly more significantly,but had no influence on cognitive function in elderly patients.
作者 李艳 张敏 张立娟 周勇 刘强 李智生 LI Yan,ZHANG Min,ZHANG Lijuan,et al(Rizhao City, Shandong Province Chinese Medicine Hospital child protection , Rizhao 276800, China)
出处 《国际精神病学杂志》 2015年第2期8-11,共4页 Journal Of International Psychlatry
关键词 帕金森病 精神障碍 利培酮 氟哌啶醇 Parkinson’s disease Mental disorder Risperidone Haloperidol
作者简介 李艳(1971.4-),女,汉族,山东省日照市人,本科,主治医师,研究方向:精神病心理咨询。E—mail:supingsupingl2345@163.com
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