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血清CA153、CA199、CA125及CEA联合检测在肿瘤诊断中的价值研究 被引量:11

The Clinical Value Study of Combined Detections of CA153, CA199, CA153 and CEA in the Diagnosis of Malignant Tumors
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摘要 目的:探讨肿瘤标志物(CA153、CA199、CA125、CEA)联合检测对乳腺癌、卵巢癌和结直肠癌的诊断价值。方法:收集自2010年1月-2013年12月在深圳市第二人民医院治疗的20例乳腺癌、28例卵巢癌、28例结直肠癌患者及39例健康人作为研究对象,分别检测其血清CA153、CA199、CA125、CEA水平并进行统计学的分析。结果:恶性肿瘤各组患者血清CA153、CA199、CA125、CEA水平显著高于健康体验者,差异有统计学意义(P〈0.05);乳腺癌中CA153水平、卵巢癌组中CA125水平、结直肠癌中CEA和CA199水平均高于其他肿瘤组,差异具有统计学意义(P〈0.05);其敏感性分别为75.0%、67.8%、60.7%和39.3%,4种肿瘤指标联合检测敏感性为85.5%,特异性92.3%,明显高于单一检测,差异具有统计学意义(P〈0.05)。结论:与单一指标比较,肿瘤标志物(CA153、CA199、CA125、CEA)联合检测能够提高诊断的敏感性,对恶性肿瘤的早期诊断有重要意义。 Objective To explore the diagnostic value of the combined detections of serum tumor markers including CA153, A199, CA125, CEA in breast cancer, ovarian cancer and colorectal carcinoma. Methods Detect and statistically analyze the levels of CA153, CA199, CA125, CEA in serum of each group of malignant tumors and healthy people. Results The serum levels of CA153, CA199, CA125, CEA in each group of malignant tumors were statistically higher than healthy people (P 〈 0.05). The serum levels of CA 153 in breast cancer group, CA 125 in ovarian group, CEA and CA 199 in colorectal group were statistically higher than other tumor groups (T 〈 0.05). Their sensitivity was 75 %, 67.8 %, 60.7 % and 39.3 % respectively. The sensitivity and specificity of combined detection of four tumor markers were 85.5% and 92.3%. Conclusion The combined detection of serum CA153, CA 199, CA 125, CEA levels could significantly improve the diagnostic sensitivity compared with solitary detection of tumor markers and had important significance for the early diagnosis of cancer.
作者 陈敏 李康成 黄铁军 CHEN Min, LI Kang-cheng, HUANG Tie-jun (Shenzhen Second People's Hospital, Guangdong Shenzhen 518035)
出处 《深圳中西医结合杂志》 2015年第5期16-18,F0003共4页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词 肿瘤标志物 CA199 CA153 CA125 癌胚抗原 联合检测 Tumor markers CA199 CA153 CAl25 Combined detection Diagnostic
作者简介 [通信作者]陈敏(Tel:13612800000;Emaih592218702@qq.com)
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