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PHB 及 mPEG-PHB 嵌段共聚物的合成与表征 预览

Synthesis and Characterization of PHB and Block Copolymer mPEG-PHB
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摘要 以β-丁内酯(BL)为单体、萘钾-冠醚为引发剂通过阴离子开环聚合合成聚(β-丁内酯)(PHB),研究了反应时间对 PHB 分子量的影响。在萘钾-冠醚引发体系的基础上制备聚乙二醇甲醚-钾大分子引发剂(mPEG-K),采用 mPEG-K 引发β-丁内酯开环聚合合成两亲性嵌段共聚物聚乙二醇甲醚-聚(β-丁内酯)(mPEG-PHB),并通过1 HNMR、FTIR、DSC 对其进行表征。通过分子自组装技术制备了 mPEG-PHB 共聚物的纳米粒子,采用 SEM、TEM、DLS 对纳米粒子进行表征。结果表明,在一定时间内 PHB 的分子量随反应时间的延长而增大。DSC 结果表明,无定形的 PHB 明显降低了结晶性 mPEG 的结晶能力。mPEG-PHB 纳米粒子为粒径在100 nm 左右的具有核壳结构的纳米微球。 Usingβ-butyrolactone(BL)as monomer,naphthalene potassium-crown ether as initiator,poly(β-butyrolactone)(PHB)was synthesized by anionic ring-opening polymerization.The effect of reaction time on molecular weight of PHB was studied.Poly(ethylene glycol)methyl ether-potassium macroinitiators(mPEG-K) was synthesized based on naphthalene potassium-crown ether.Amphiphilic poly(ethylene glycol)methyl ether-poly(β-butyrolactone)(mPEG-PHB)was prepared by ring-opening polymerization of BL initiated by mPEG-K. Copolymer was characterized by 1 HNMR,FTIR,DSC.The copolymer nanoparticles were prepared by the mo-lecular self-assemble technology.These nanoparticles were characterized by SEM,TEM,DLS.The results showed that the molecular weight of PHB increased with reaction time in a certain time.The DSC results showed that amorphous PHB reduced the crystallization ability of mPEG significantly.These nanoparticles were core-shell structure nanospheres with size of 100 nm.
作者 李雪梅 贺继东 代元坤 张晶晶 戎佳萌 LI Xue-mei, HE Ji-dong, DAI Yuan-kun, ZHANG Jing-jing, RONG Jia-meng (Key Laboratory of Rubber-Plastics of Ministry of Education, Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science & Technology, Qingdao 266042, China)
出处 《化学与生物工程》 CAS 2015年第5期43-47,共5页 Chemistry & Bioengineering
关键词 β-丁内酯 阴离子聚合 聚乙二醇甲醚 两亲性 纳米微球 β-butyrolactone anionic polymerization poly(ethylene glycol)methyl ether amphiphilic nano-sp heres
作者简介 李雪梅(1989-),女,山东威海人,硕士研究生,研究方向:生物医用高分子材料;通讯作者:贺继东,教授,E-mail:hid@qust.edu.cn。
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