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献血者红细胞不规则抗体检测在电子交叉配血技术中的应用分析 被引量:9

Analysis of irregular antibody screening irregular in donors' red blood cell for the development of electronic crossmatch
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摘要 目的调查东莞市及文献报道无偿献血者红细胞不规则抗体的发生频率、类型,为电子交叉配血的开展提供基础。方法 2013年7月21日-2014年4月16对在本市无偿献血的献血者血标本进行红细胞不规则抗体检测,并对其结果及文献数据进行统计分析。结果 59 677人份无偿献血者血样中共检出红细胞不规则抗体阳性129例,其中男81例,女48例,总阳性率0.216%,国内文献报道了572 959例无偿献血者不规则抗体的检测结果,检出193例阳性,阳性率0.034%,远低于国外报道的0.43%(P〈0.01)。Ig M型不规则抗体95例,远高于Ig G型34例(P〈0.01),不规则抗体与效应细胞的凝集强度〈"2+"的达到88.37%(114/129)。女性不规则抗体阳性率0.286%,显著高于男性0.189%(P〈0.01)。结论本市无偿献血者红细胞不规则抗体阳性率为0.216%,以Ig M型抗体为主。考虑存在安全隐患,建议开展电子交叉配时进行献血者不规则抗体筛选。 Objective To investigate the frequency and types of rod blood cell (RBC) irregular antibody in donors from Dongguan and reported literature, and to provide the basis for electronic crossmatch. Methods The RBC irregular antibodies in blood samples were screened from donors in Dongguan from July 21st, 2013 to April 16th, 2014. From the results obtained from the screening and data from literature, a statistical' analysis was carried out. Results There were 129 cases which were positive for RBC irregular antibody in 59 677 cases of blood donors' blood sample. Among the 129 cases, 81 cases were males and 48 cases were females, at a positive rate of 0. 216%. Literature reported that 193 out of 572 959 cases were positive cases, at a rate of 0. 034%, which was far lower than the rate reported abroad at 0. 43% ( P 〈 0. 01 ). The number of IgM irregular antibodies was much higher than that of IgG irregular antibodies ( P 〈 0. 01 ). 88.37 % of irregular antibodies and effeetor cells achieved a ( 114/129 ) level of agglutination intensity below "2 + ". The positive rate of irregular antibody in females (37.21% ) was significantly lower than in males (62. 79% ) ( P 〈 0. 01 ). Conclusion The positive rate of RBC irregular antibody in donors from Dongguan was 0. 216%. The types of antibodies were dominated by IgM antibody. Irregular antibody screening is recommended when developing electronic crossmatch in Dongguan.
作者 邹文涛 何子毅 王庆 陈庆恺 邹姣丽 陆家海 ZOU Wentao, HE Ziyi, WANG Qing, CHEN Qingkai, ZOU Jiaoli, LU Jiahai(1. Department of Public Health, Sun Yat-Sen University, Dongguan 510080, China; 2. Dongguan Blood Center)
出处 《中国输血杂志》 CAS 北大核心 2015年第5期533-536,共4页 Chinese Journal of Blood Transfusion
基金 东莞市医疗卫生科技计划一般项目(2013051010020)
关键词 无偿献血者 红细胞 不规则抗体 电子交叉配血 blood donors red blood cell irregular antibody electronic crossmatch
作者简介 通信作者:陆家海(1964.5-),男,医学博士,教授,博士生导师,主要从事流行病学和one health教学和研究工作.电话:020—87332438,Email:lujiahai@mail.sysu.edu.cn
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