Objective：Investigating the current situation in treatment on female stromal tumors misdiagnosed as gynecologic tumors of China from 2003 to 2013. Methods： 2 misdiagnosed cases as gynecologic tumors in the 454 hospital of PLA and 33 relative literatures were reviewed,in a total of 63 cases. Results： 1Diagnosis and treatment. There were 51 cases of GIST and 12 cases of EGIST. All were diagnosed accurately only by routine postoperative pathological diagnosis. One case was performed biopsy prior to operation and 18 were given intraoperative frozen section, which failed to confirm the diagnosis. After operation,4 cases took oral administration of imatinib mesylate,one case was given intravenous chemotherapy with cyclophosphamide and cisplatin for a course of treatment. 2The stromal tumor origin. In 51 cases GIST, 36 cases from small intestine;each 3 from small bowel mesentery and ileum;and 2 from stomach;1 from jejunum,colon,right colon,cecum,appendix each; 2 from intestinal（unrecorded parts）. 12 cases EGIST：4 cases were from intraperitoneal; 3 from ovarian,2 from broad ligament,and 1 from uterine bladder peritonea; 2 from vaginal wall. 3 11 cases were recorded of follow-up,4 have been dead,2 were halfway lost,5 cases were normal. Conclusions：The main methods to completely cure early-stage stromal tumor is tumor removal operation. Inappropriate biopsy may cause tumor rupture,hemorrhage and increased a danger of tumor dissemination. The cases suspected of tumor metastasis in lymph node or other malignant tumors,may be considered to be treated with the frozen biopsy,without routine pelvic lymph node resction. The cases which are not sensitive to chemotherapy and radiotherapy can assist with the molecular targeted drug therapy to prevent,reduce and delay the recurrence and metastasis of tumor.
Foreign Medical Sciences（Obstet Gynecol Fascicle）
Gastrointestinal stromal tumors