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氟哌噻吨美利曲辛片改善帕金森病患者抑郁症状临床观察 被引量:1

The clinical effect observation of flupentixol and melitracen tablets to improve depressive symptoms in patients with Parkinson disease
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摘要 目的观察氟哌噻吨美利曲辛片(黛力新)对帕金森病患者抑郁症状的改善作用。方法将56例帕金森病患者按照随机数字表法随机分为观察组和对照组各28例。观察组采用黛力新治疗;对照组采用常规方法治疗。比较2组患者汉密尔顿抑郁量表(HAMD)评分、抑郁症状的临床疗效及不良反应。结果 2组患者治疗前的HAMD评分比较差异无统计学意义(P〉0.05)。治疗后观察组1、2、4、6周时的HAMD评分均低于对照组,总有效率为96.43%高于对照组的64.29%,不良反应发生率明显低于对照组,差异均有统计学意义(P〈0.05)。结论黛力新能够有效改善帕金森病患者的抑郁症状,疗效显著、安全可靠。 Objective To observe the clinical effect of flupentixol and melitracen tablets( Deanxit) on the clinical symptoms of depression in patients with Parkinson disease. Methods 56 patients with Parkinson's disease were randomly divided into observation group and control group with 28 cases in each group. The observation group was treated with Deanxit; the control group was treated by conventional methods. The clinical efficacy and adverse reactions of the Hamilton Depression Rating Scale( HAMD) score and depressive symptoms between the two groups were compared. Results Before treatment,there was no significant difference in HAMD score between the two groups( P 0. 05). After treatment,the HAMD score of the observation group 1,2,4,6 weeks after treatment were lower than that of the control group,the differences were statistically significant( P 0. 05). The total effective rate of the observation group was 96. 43%,which was higher than 64. 29% in control group( P 0. 05). Conclusion Deanxit can effectively improve depressive symptoms in patients with Parkinson's disease. The curative effect is remarkable,safe and reliable.
作者 薛晓琳 XUE Xiao-lin ( Department of Neurology ,People's Hospital of Guanyun County ,Jiangsu 222200, China)
出处 《临床合理用药杂志》 2015年第22期9-10,共2页
关键词 帕金森病 氟哌噻吨美利曲辛片 抑郁情况 不良反应 Parkinson's disease Flupentixol and melitracen tablets Depression Adverse reactions
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