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姜黄素磷脂复合物不同制剂对SD大鼠口服生物利用度的影响 预览 被引量:8

The bioavailability influence of oral curcumin-phospholipid complex preparations on SD rats
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摘要 目的比较姜黄素磷脂复合物以水分散体、固体分散体及油制剂形式给药时对SD大鼠口服吸收生物利用度的影响。方法 SD大鼠分别灌胃给予姜黄素磷脂复合物上述3种制剂,取血,以大黄素为内标,HPLC法测定姜黄素的血药浓度,并计算药动学参数。结果姜黄素磷脂复合物油制剂的曲线下面积(AUC0-∞)分别为原料药、水分散体及固体分散体的7.99、1.58和1.46倍,而且其tmax与t1/2也均有所延长。结论姜黄素磷脂复合物以油制剂给药时,可显著地提高其生物利用度,这可能与其在油中有更高的稳定性有关。 AIM To study the bioavailability influence of oral preparations of curcumin-phospholipid complex( including aqueous dispersion,solid dispersion and oil-based formulation) on SD rats. METHODS After each of three groups of SD rats was administered intragastrically with one of the three different preparations respectively,their blood samples were collected at different time intervals. The curcumin concentrations were detected by HPLC with emodin as the internal standard,and thus the pharmacokinetic parameters were calculated and obtained. RESULTS The AUC0- ∞for oil-based preparation of curcumin-phospholipid complex was 7. 99,1. 58 and 1. 46 times of the crude drug,aqueous dispersion and solid dispersion,respectively,their tmaxand t1 /2were also extended to some extent. CONCLUSION Manifesting a better stability in oil,the bioavailability of curcumin-phospholipid complex is greatly enhanced by oil-based preparation.
作者 吴先闯 郝海军 张永州 宋晓勇 刘瑜新 张红芹 WU Xian-chuang,HAO Hai-jun,ZHANG Yong-zhou,SONG Xiao-yong,LIU Yu-xin,ZHANG Hong-qin( 1. Huaihe Hospital of Henan University, Kaifeng 475000, China ; 2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China ; 3. National Engineering Research Center for Traditional Chinese Medicine, Shanghai 201203, China)
出处 《中成药》 CAS CSCD 北大核心 2015年第10期2163-2166,共4页 Chinese Traditional Patent Medicine
基金 河南省科技发展计划项目(144300510019)
关键词 姜黄素 磷脂复合物 SD大鼠 生物利用度 水分散体 固体分散体 油制剂 curcumin phospholipid complex SD rats bioavailability aqueous dispersion solid dispersion oil-based preparation
作者简介 吴先闯(1985-),男,硕士,主管药师,从事临床药学研究。Tel:(0371)23906379,E-mail:wuxc128@126.com 通信作者:宋晓勇,男,教授,主任药师,从事临床药学研究。Tel:(0371)23906970,E-mail:sxyjk@sina.com
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