【目的】观察加味四君子汤对力竭性运动引起的机体体液免疫功能下降的影响。【方法】选用30只SD大鼠经适应性训练后,剔除死亡或不适应大鼠6只,将其他24只SD大鼠随机分为正常组、运动模型组、加味四君子汤组（剂量为8 g/只）。正常组不予任何处理,自由饮食;运动模型组与加味四君子汤组采用运动性力竭训练,造模成功后分别灌胃蒸馏水或加味四君子汤。3组于61 d后即刻取材,检测各组血清免疫球蛋白IgA、IgG、IgM与补体C3、C4含量。【结果】加味四君子汤组免疫球蛋白IgA、IgG、IgM和补体C3、C4含量显著升高,与模型组比较,差异均有统计学意义（P〈0.01）。【结论】加味四君子汤能够有效延缓运动过程中的免疫能力低下。
Objective To observe the influence of modified Sijunzi Decoction on the decrease of immune function of exercise-induced exhaustion rats. Methods Thirty SD rats were given adaptive training, and then 6 dead or nonadaptive rats were dropped out. The remaining 24 SD rats were randomly divided into normal group（ N = 8）,model group（ N = 8）, and modified Sijunzi Decoction group（ MSD group, N = 8）. Normal group did not receive any medication and took diet freely. The rats of model group and MSD group were orally given distilled water or modified Sijunzi Decoction 8 g per day respectively after the modeling by exercise-induced exhaustion.After 61 days, the serum was taken from the three groups, and immunoglobulin lg A, lg G, lg M, and complement C3,C4 were detected. Results The contents of immunoglobulins Ig A, Ig G, Ig M and complements C3, C4 in MSD group were higher than those in the model group（ P〈0.01）. Conclusion The decrease of immunity occurs in the process of exercise stress, but can be delayed by modified Sijunzi Decoction..
Journal of Guangzhou University of Traditional Chinese Medicine
Exercise-induced exhaustion/TCD therapy
Modified Sijunzi Decoction/pharmacology