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Evi1基因阳性急性髓细胞白血病14例临床分析

Clinical analysis of 14 acute myeloid leukemia patients with Evi1 gene positive
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摘要 目的:分析Evi1基因阳性急性髓细胞白血病(AML)患者的临床特征以及预后特点。方法:收集14例Evi1基因阳性AML患者的临床以及实验室资料,其中男、女各7例,中位年龄49(31~67)岁,初诊时白细胞计数(27.50±41.61)×109/L,血红蛋白(75.50±20.92)g/L,血小板计数(42.86±46.73)×109/L,骨髓原始细胞百分比(49.60±23.30)%。3例由骨髓增生异常综合征(MDS)转化而来,伴有病态造血的比例为42.86%(6/14),表现为髓系形态异常。存在染色体异常的比例为22.22%(2/9),其中伴有3号染色体异常1例,7号染色体缺失1例。结果:14例患者中12例进行诱导化疗,5例(41.67%)获得完全缓解,患者中位生存时间为122.5(10~562)d,12个月总体生存率为47.9%,18个月总体生存率为16.0%。结论:Evi1基因阳性AML常常伴有不同程度的病态造血,且与MDS转化有关,其治疗后的完全缓解率低,总体生存期短,预后差。 Objective:To analyze the clinical characters and prognostic features of acute myeloid leukemia patients with Evi1 gene positive.Method:We included 14 adult AML patients(7 males and 7 females,aged 31 to 67years,median 49years)with Evi1 gene positive.At diagnosis,WBC was(27.50±41.61)×109/L,HGB was(75.50±20.92)g/L,PLT was(42.86±46.73)×109/L,bone marrow blast was(49.60±23.30)%.Three patients were transformed from MDS,and proportion with dysplasia was 42.86%(6/14),which mainly manifested myeloid morphologic abnormalities.The proportion of parents with chromosomal abnormalities was 22.22%(2/9),one with chromosome 3 abnormality and the other with missing chromosome 7.Result:Twelve of 14 patients received induction chemotherapy,and the complete remission rate was 41.67%(5/12).The median survival time was 122.5(10to 562)days.One-year overall survival rate was 47.9% and 18 months overall survival rate was 16.0%.Conclusion:Evi1gene positive AML patients have high proportion dysplasia and relate to MDS transformation,besides the patients have low complete remission,short overall survival and poor prognosis.
作者 周强 马洪兵 刘作凤 崔旭 陈心传 李建军 郑沁 余江 刘霆 贾永前 ZHOUQiang MA Hongbing LIUZuofeng CUI Xu CHEN Xinchuan LI Jianjun ZHENG Qin YU Jiang LIU Ting JIA Yongqian (1 Department of Hematology, Laboratory of Hematology ~ 2 Department of Experiment Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China)
出处 《临床血液学杂志》 CAS 2015年第6期949-953,共5页 Journal of Clinical Hematology
关键词 Evi1基因 白血病 髓细胞 急性 临床特征 预后 Evi1 gene acute myeloid leukemia clinical character prognosis
作者简介 通信作者:贾永前,E-mail:jia_yq@163.com
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