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HBsAg定量与HBV-DNA联合检测在慢性乙型肝炎中的临床意义 预览 被引量:8

Clinical Significance of Combined Detection of HBsAg and HBV-DNA in Patients with Chronic Hepatitis B
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摘要 目的探讨慢性乙型肝炎病毒(HBV)感染患者表面抗原定量检测与HBV-DNA相关性,并探讨其检测临床意义。方法检测2010年12月至2012年12月200例未接受抗病毒治疗及免疫调节剂治疗的慢性HBV感染患者治疗前、治疗中HBsAg与HBV.DNA水平,并随访20例治疗后HBV-DNA转阴患者HBsAg与HBV-DNA水平变化,探究HBsAg定量检测临床意义。结果慢性乙型肝炎患者未接受抗病毒治疗及免疫调节剂治疗前HBeAg(+)患者HBsAg与HBV-DNA水平显著正相关(r=0.683,P〈0.05),HBeAg(-)患者两者正相关性,但相关性较低(r=0.273,P〈0.05)。治疗过程中HBsAg与HBV-DNA水平呈正相关(r=0.41,P〈0.01),65.5%(131/200)的变化规律为HBsAg随HBV-DNA含量的下降而下降。20例HBV-DNA治疗后转阴(HBV-DNA〈500拷贝/mL)患者,其中6例治疗期间HBsAg定量持续下降,HBsAg定量均〈250IU/mL,停药后24周复检HBV-DNA仍为阴性。14例治疗后乙肝病毒定量转阴患者(HBV.DNA〈500拷贝/mL),治疗期间HBsAg定量不降或上升,停药后24周复检病毒定量有4例(4/14)出现反弹(HBV-DNA〉500拷贝/mL)。结论血清HBsAg含量与I-IBV-DNA具有相关性,临床可将HBsAg含量与HBV-DNA联合检测,用于慢性HBV感染患者的病情程度预判,监测临床治疗疗效。 Objective To explore the clinical significance of combined detection of HBsAg and HBV-DNA in patients with chronic Hepatitis B. Methods 200 cases of chronic Hepatitis B patients without antiviral and immunomodulatory treatment was selected in this study. The HBsAg and HBV-DNA levels in patients before and after treatment were detected and followed up 20 cases patient with HBV-DNA changed to negative. Results The levels of HBsAg in chronic Hepatitis B patients without antiviral and immunomodulatory treatment was significantly positively correlated with the level of HBV- DNA ( P 〈 0.05 ). In the process of treatment, the HBsAg levels were decrease with HBV-DNA content decrease. The HBV-DNA in 20 cases of patients was changed to negative after treatment, and the HBsAg levels in 6 cases continued to decline and still keep negative at 24 weeks after stopping treatment. Conclusion There is some extent correlation between serum HBsAg and HBV-DNA in patients with chronic Hepatitis B. The combined detection of HBsAg with HBV-DNA could be can be used for forecasting the condition of patients and monitoring the treatment effect in chronic Hepatitis B patients.
作者 矫淑媛 张学平 JIAO Shu-yuan, ZHANG Xue-ping (Anshan Central Hospital, The sixth Clinical College of China Medical University, Anshan 114001, China)
出处 《标记免疫分析与临床》 CAS 2015年第12期1245-1247,1213共4页 Labeled Immunoassays and Clinical Medicine
关键词 慢性乙型肝炎 乙肝表面抗原 乙肝病毒DNA Chronic hepatitis B HBsAg HBV- DNA
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  • 1慢性乙型肝炎防治指南[J].中华传染病杂志,2005,23(6):421-431. 被引量:820
  • 2窦亚玲,李永哲,刘志肖,高学慧,王巧凤,倪安平.乙型肝炎病毒前S1抗原检测的临床价值[J].中华检验医学杂志,2006,29(8):714-716. 被引量:90
  • 3王艳.HBV感染者血清标志物HBeAg阳性与HBeAg阴性模式HBV-DNA检测结果的比较分析[J].江西医药,2007,42(1):62-63. 被引量:4
  • 4中华医学会传染病与寄生虫病学分会 肝病学分会.病毒性肝炎防治方案[J].中华传染病杂志,2001,. 被引量:256
  • 5Visvanathan K,Skinner NA,Thompson AJ,et al.Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein.Hepatology,2007,45:102-110. 被引量:1
  • 6Boni C,Fisicaro P,Valdatta C,et al.Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection.J Virol,2007 ;81:4215-4225. 被引量:1
  • 7Lau GK,Suri D,Liang R,et al.Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen.Gastroenterology,2002,122:614-624. 被引量:1
  • 8Evans A, Riva A,Cooksley H,et al. Programmed death 1expression during antiviral treatment of chronic hepatitis B:Impact of hepatitis B e-antigen seroconversion.Hepatology,2008,48:759-769. 被引量:1
  • 9Stoop JN,vander Molen RG,Kuipers E J,et al.Inhibition of viral replication reduced regulatory T cells and enhances the antiviral immune response in chronic hepatitis B.Virology,2007,361:141-148. 被引量:1
  • 10Rossol S,Marinos G,Carucci P,et al.Interleukin-12 induction of Thl cytokines is important for viral clearance in chronic hepatitis B.J Clin Invest,1997,99:3025-3033. 被引量:1

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