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昕泰治疗多发性骨髓瘤的有效性及安全性研究 预览

Efficacy and Safety of XinTai~? in the Treatment of Multiple Myeloma
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摘要 目的:探讨以昕泰为主的化疗方案治疗多发性骨髓瘤的临床疗效及不良反应。方法:选取我院血液内科2018年1月~2018年4月收治的29例多发性骨髓瘤患者,按用药不同分为昕泰组(国产硼替佐米)和万珂组(进口硼替佐米),分析两组的疗效及不良反应。结果:昕泰组和万珂组的平均治疗疗程数分别为2.2和2.0,总有效率(ORR)分别为86.67%和85.71%,完全缓解率(CR)分别为13.33%和21.43%,均无统计学差异(均P>0.05)。昕泰组神经毒性作用(6.67%)低于万珂组(28.57%),但差异无统计学意义(P>0.05)。3例肾功能不全患者,其中昕泰组1例,万珂组2例,治疗2个疗程后肾功能均逆转。结论:国产硼替佐米(昕泰)在治疗多发性骨髓瘤中,临床有效性及安全性与进口硼替佐米(万珂)相当。 Objective:To investigate the clinical efficacy and adverse effects of XinTai~?-based chemotherapy in the treatment of multiple myeloma.Methods:Twenty-nine patients with multiple myeloma were enrolled in the department of hematology from January 2018 to April 2018.They were divided into XinTai~?group(domestic bortezomib)and Velcade~?group(imported bortezomib).The efficacy and safety of the two groups were retrospectively analyzed.Results:The mean number of treatment courses in XinTai~?group and Velcade~?group were 2.2 and 2.0,respectively.The overall response rate(ORR)was 86.67%and 85.71%in XinTai~?group and Velcade~?group,with complete remission(CR)rate of 13.33%and 21.43%,respectively(all P>0.05).The rate of peripheral neuropathy was 6.67%in XinTai~?group,which was lower than that of Velcade~?group(28.57%),with no statistically significant difference(P>0.05).There were 3 cases of renal insufficiency,including 1case in XinTai~?group and 2 cases in Velcade~?group,whose renal function were all reversed after 2 courses of treatment.Conclusion:The efficacy and safety of XinTai~?are comparable to that of Velcade~?in the treatment of multiple myeloma.
作者 蔡惠丽 田铭 商安芳 李柏华 王海燕 郭静明 Cai Huili;Tian Ming;Shang Anfang;Li Baihua;Wang Haiyan;Guo Jingming(Department of Hematology,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University&Institute of Hematology,China Three Gorges University,Yichang 443003,China)
出处 《巴楚医学》 2018年第4期22-25,共4页 Bachu Medical Journal
基金 湖北省自然科学基金青年项目(No:2017CFB334) 湖北省教育厅科学研究项目(No:B2017018) 湖北省卫生和计划生育委员会科研项目(No:WJ2017M222) 宜昌市科技局卫生医疗项目(No:K16-01).
关键词 多发性骨髓瘤 硼替佐米 化疗 multiple myeloma bortizomib chemotherapy
作者简介 蔡惠丽,女,博士,主治医师,研究方向为恶性血液疾病、出凝血疾病的基础及临床。E-mail:fjcaihuili@sina.com;通讯作者:郭静明,男,硕士,主任医师,研究方向为慢性粒细胞白血病的基础及临床。E-mail:gjm425@163.com.
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