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恩替卡韦治疗HBeAg阳性慢性重度乙型肝炎临床疗效观察 预览 被引量:1

Observation of clinical effect by entecavir in the treatment of HBeAg positive chronic severe hepatitis B
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摘要 目的探讨恩替卡韦(ETV)治疗乙型肝炎e抗原(HBeAg)阳性慢性重度乙型肝炎的临床疗效。方法 140例HBeAg阳性慢性重度乙型肝炎患者,随机分为研究组与对照组,每组70例。对照组患者应用拉米夫定(LAM)治疗,研究组予以恩替卡韦治疗。分析对比两组患者丙氨酸转氨酶(ALT)复常、HBeAg转阴、乙型肝炎病毒脱氧核糖核酸(HBV-DNA)转阴情况。结果研究组患者HBeAg转阴、HBV-DNA转阴、ALT复常情况均优于对照组,对比差异均有统计学意义(P〈0.05)。结论恩替卡韦治疗HBeAg阳性慢性重度乙型肝炎效果明显,值得临床应用。 Objective To investigate clinical effect by entecavir(ETV) in the treatment of hepatitis B e antigen(HBe Ag) positive chronic severe hepatitis B. Methods A total of 140 patients with HBe Ag positive chronic severe hepatitis B were randomly divided into research group and control group, with 70 cases in each group. The control group received lamivudine(LAM) for treatment, and the research group received entecavir for treatment. Analysis and comparison were made on normalization of alanine aminotransferase(ALT), and negative conversion of HBe Ag and hepatitis B virus deoxyribonucleic acid(HBV-DNA). Results The research group had all better normalization of ALT, and negative conversion of HBe Ag and HBV-DNA than the control group, and their differences all had statistical significance(P〈0.05). Conclusion Entecavir provides remarkable effect in treating HBe Ag positive chronic severe hepatitis B, and it is worth clinical application.
作者 曹晓青 CAO Xiao-qing( Henan Shangqiu City First People's Hospital, Shangqiu 476000, China)
出处 《中国现代药物应用》 2016年第4期1-3,共3页
关键词 慢性重度乙型肝炎 乙型肝炎e抗原阳性 恩替卡韦 Chronic severe hepatitis B Hepatitis B e antigen positive Entecavir
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