Objective To observe application of tamoxifen and toremifene in moderate and severe premenopansal eyelomastopathy. Methods A total of 300 patients with moderate and severe premenopaasal cyclomastopathy were divided by different medication into application group and control group, with 150 cases in each group. The application group received toremifene for treatment, and the control group received tamoxifen for treatment. Comparisons were made on curative effects between the two groups after a period of drug administration. Results Total effective rate was 98% in the application group and was 86% in the control group. The application grouphad better total effective rate than the control group, and the difference had statistical significance （P〈0.05）. Conclusion Implement of toremifene in moderate and severe premenopausal eyclomastopathy can provide much better effect than tamoxifen. It can remarkably relieve breast pain in patients, and improve curative effect and ensure quality of life. This method is worthy of clinical promotion and application.
China Practical Medical
Moderate and severe