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健脾活血利水汤治疗乙肝肝硬化腹水的疗效及安全性 预览 被引量:4

Safety and efficacy of Jianpi Huoxue Lishui Decoction in the treatment of hepatitis B cirrhosis ascites
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摘要 目的 观察健脾活血利水汤治疗脾虚血瘀水停型乙肝肝硬化腹水的有效性及安全性。方法 将乙肝肝硬化腹水患者108例随机分为观察组54例和对照组54例。对照组采用西医基础治疗方案,包括限水、限钠,保肝利尿治疗,观察组在对照组治疗基础上给予健脾活血利水汤,4周为1个疗程,2组均治疗1个疗程,观察患者症状体征、腹水改善情况及肝功能等指标,评估临床疗效及安全性。结果 观察组总有效率明显高于对照组(P〈0.05)。2组治疗后谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)水平均较治疗前显著下降(P均〈0.05),白蛋白(ALB)水平较治疗前明显上升(P〈0.05),上述指标治疗后组间比较差异有统计学意义(P〈0.05)。2组凝血酶原时间(PT)时间较治疗前明显降低(P〈0.05),凝血酶原活动度(PTA)较治疗前明显上升(P〈0.05),2组PT时间及PTA治疗后组间比较差异有统计学意义(P均〈0.05)。2组腹围、门静脉内径较治疗前明显缩小(P均〈0.05),24 h尿量较治疗前明显增加(P〈0.05),而2组脾脏厚度与治疗前比较无明显变化。2组治疗后腹围、24 h尿量及门静脉内径比较差异有统计学意义(P均〈0.05)。结论 在西药常规治疗基础上应用健脾活血利水汤治疗乙肝肝硬化腹水可提高临床疗效,改善肝功能和凝血功能,为患者获得更好的远期疗效奠定基础。 Objective It is to observe the efficacy and safety of Jianpi Huoxue Lishui Decoction (JPHXLSD) in treating spleen deficiency and blood stasis and water stop type hepatitis B cirrhosis ascites. Methods 108 cases of patients with liver cirrhosis and ascites were randomly divided into observation group and control group with 54 cases in each group. The patients of control group were treated with western medicine foundation treatment scheme, including the limited water and sodium re- striction, protecting liver and diuresis. The patients of observed group were received JPHXLSD on the basis of the control group, 4 weeks for a course of treatment, treated for one course in both groups, the symptoms and signs, improve of ascites and liver function index were observed, and the clinical efficacy and safety were evaluated. Results The total effective rate of observation group was significantly higher than that of the control group ( P 〈 0.05). Compared with before treatment, two groups of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil) levels were decreased significantly after treatment ( all P 〈 0.05 ) , and the level of albumin (ALB) were increased significantly ( all P 〈 0.05 ) , there were significant difference in these indexes between the two groups ( all P 〈 0.05). Two groups of prothrombin time (PT) were significantly decreased and prothrombin activity (PTA) were significantly increased than before treatment (all P 〈 0.05 ) , and there were significant difference between the two groups (P 〈 0.05). The abdominal circumference, diameter of portal vein of the two groups were significantly reduced than before treatment ( all P 〈 0.05 ) , and 24 h urine volume were in- creased significantly (all P 〈 0.05) , but there was no significant difference in thickness of spleen between the two groups. There were significant difference in abdominal circumference, 24 h urine volume and the inner diameter of portal v
作者 李淑红 刘华一 唐艳萍 LI Shuhong, LIU Huayi, TANG Yanping(1 Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300100, China; 2 Tianjin Academy of TCM Affiliated Hospital, Tianjin 300120, China)
出处 《现代中西医结合杂志》 CAS 2016年第9期944-947,共4页 Modern Journal of Integrated Chinese Traditional and Western Medicine
关键词 健脾活血利水汤 乙肝 肝硬化腹水 脾虚血瘀水停型 Jianpi Huoxue Lishui Decoction hepatitis B liver cirrhosis ascites spleen deficiency and blood stasis type and water stop type
作者简介 李淑红,女,博士在读,研究方向为消化系统疾病。
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