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焦虑对帕金森病患者运动功能和认知功能的影响 被引量:5

EFFECT OF ANXIETY ON MOTOR AND COGNITIVE FUNCTION IN PATIENTS WITH PARKINSON'S DISEASE
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摘要 目的探讨焦虑对帕金森病(Parkinson's disease,PD)患者运动功能和认知功能的影响。方法 60例PD患者,采用汉密尔顿焦虑量表14项版本(Hamilton Anxiety Scale-14,HAMA14)评测患者焦虑情绪、简易智能精神状态检查量表(Mini-Mental State Examination,MMSE)和蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评定患者认知功能、统一帕金森病评定量表第三部分(Unified Parkinson's Disease Rating Scale PartⅢ,UPDRSⅢ)和Hoehn-Yahr分期评测患者运动功能和病情严重程度。分析焦虑对PD患者运动功能和认知功能的影响。结果 60例患者中,27例(45%)存在焦虑,焦虑与非焦虑组之间的UPDRSⅢ、MMSE和MoCA评分差异有统计学意义(P〈0.05);60例患者中,17例(28.33%)为轻度运动功能障碍,43例(71.67%)为中重度运动功能障碍,二组间病程、HAMA14、Hoehn-Yahr分期之间存在差异(P〈0.05),并且焦虑(OR=4.280,OR95%CI=1.081~16.937,P=0.038)和病程(OR=6.717,OR95CI=1.743~25.895,P=0.006)是运动功能障碍加重的危险因素。60例患者中,18例(30%)为认知功能正常,26例(43.33%)为轻度认知功能障碍(mild cognitive impairment,MCI),16例(26.67%)为痴呆,三组之间年龄、UPDRSⅢ、HAMA14差异有统计学意义(P〈0.05),并且年龄(OR=4.290,OR95%CI=1.133~16.235,P=0.032)和焦虑(OR=4.274,OR95%CI=1.041~17.555,P=0.044)为认知功能障碍发生的危险因素。结论焦虑对PD患者的运动及认知功能有影响,并且是运动功能障碍加重和认知功能障碍发生的危险因素。 Objective To explore the effect of anxiety on motor and cognitive function in patients with Parkinson's disease(PD).Methods Totally 60 patients were enrolled in this study.Hamilton Rating Anxiety Scale(14-item version,HAMA14)was used to evaluate the anxiety.Mini- Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)were used to evaluate cognitive function.The third part of Unified Parkinson's Disease Rating Scale(UPDRSⅢ)was used to evaluate the motor function of the patients,Hoehn-Yahr stage was used to evaluate the severity of disease.Logistic regression analysis was used to analysis the effect of anxiety on motor and cognitive function.Results Among 60 patients,27(45%)were in anxiety and 33(55%)were without anxiety.There was a difference in UPDRSⅢ,MMSE and MoCA scores between two groups(P〈0.05).17(28.33%)of them were in mild motor dysfunction and 43(71.67%)were in moderate serious motor dysfunction.There was a difference in duration,HAMA14 and Hoehn-Yahr stage between two groups(P〈0.05).Anxiety(OR=4.280,OR95%CI=1.081~16.937,P=0.038)and duration(OR=6.717,OR95CI=1.743~25.895,P=0.006)were the risk factors of motor dysfunction.18(30%)of 60 PD patients were in normal cognitive function,26(43.33%)were in MCI and 16(26.67%)were in dementia.There was a difference in age,UPDRSⅢ and HAMA14 among three groups.Anxiety(OR=4.274,OR95%CI=1.041~17.555,P=0.044)and age(OR=4.290,OR95%CI=1.133~16.235,P=0.032)were the risk factors of cognitive impairment.Conclusions Anxiety has an effect on motor function and cognitive,and is a risk factor of motor function dysfunction and cognitive impairment.
作者 王大力 石松鑫 顾平 刘俊骞 解冰川 刘惠苗 Wang Dali , Shi Songxin , Gu Ping ,et al.( Second Department of Neuroscience , North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China)
出处 《中国煤炭工业医学杂志》 2016年第4期626-629,共4页 Chinese Journal of Coal Industry Medicine
基金 2013年河北省卫生厅医学科学研究课题计划项目(编号:20130281)
关键词 帕金森病 焦虑 运动功能 认知功能 Parkinson's disease Anxiety Motor function Cognitive function
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参考文献15

  • 1Zhang ZX,Roman GC,Hong Z,et al.Parkinson's disease in China:prevalence in Beijing,Xian and Shanghai[J].Lancet,2005,365:595-597. 被引量:1
  • 2韩英,刘楠,黄慧玲,徐春平,晏泽辉.帕金森病患者伴发抑郁对认知障碍和运动障碍的影响[J].福建医科大学学报,2013,47(4):232-235. 被引量:6
  • 3Gelb GJ,Oliver E,Gilman S.Diagnostic criteria for Parkinson's disease[J].Arch Neurol,1999,56:33-39. 被引量:1
  • 4Leentjens AF,Dujardin K,Marsh L,et al.Anxiety rating scales in Parkinson's disease:a validation study of the Hamilton anxiety rating scale,the Beck anxiety inventory,and the hospital anxiety and depression scale[J].Mov Disord,2011,26(3):407-415. 被引量:1
  • 5马羽,孟凡刚,胡文瀚,葛明,张凯,杨岸超,王慧敏,张建国,冯涛.国产脑深部电刺激系统治疗帕金森病的临床初步研究[J].中华神经外科杂志,2013,29(9):920-923. 被引量:10
  • 6Djamshidian A,Friedman JH.Anxiety and depression in Parkinson's disease[J].Curr Treat Options Neurol,2014,16(4):285. 被引量:1
  • 7DissanayakaNN,Sellbach A,Matheson,et al.Anxiety disorder in Parkinson's disease:prevalence and risk factor[J].Movdisord,2010,25(7):838-845. 被引量:1
  • 8刘卓,孙莉,黄曦妍,曹辰杰,余舒扬,左丽君,杨雅琴,朴英善,张巍.帕金森病伴发焦虑与运动症状及非运动症状关系的研究[J].中华临床医师杂志(电子版),2012,6(2):12-17. 被引量:14
  • 9Dissanayaka NN,White E,O'Sullivan JD,el at.The clinical spectrum of anxiety in Parkinson's disease[J].MovDisord,2014,29(8):967-975. 被引量:1
  • 10Ceravolo R,Frosini D,Poletti M,et al.Mild affective symptoms in de novo Parkinson's disease patients:relationship with dopaminergic dysfunction[J].Eur J Neurol,2013,20:480-485. 被引量:1

二级参考文献73

  • 1张振馨,.帕金森病的诊断[J].中华神经科杂志,2006,39(6):408-409. 被引量:539
  • 2朱慧颖,朱遂强.影响帕金森病患者生活质量的因素[J].中国康复,2007,22(3):169-171. 被引量:7
  • 3Remy P,Doder M,Lees A,et al.Depression in Parkinson's disease:loss of dopamine and noradrenaline innervation in the limbic system.Brain,2005,128:1314-1322. 被引量:1
  • 4Dissanayaka NN,Sellbach A,Matheson S,et al.Anxiety disorders in Parkinson's disease:prevalence and risk factors.Mov Disord,2010,25:838-845. 被引量:1
  • 5Kummer A,Cardoso F,Teixeira AL.Generalized anxiety disorder and the Hamilton Anxiety Rating Scale in Parkinson's disease.Arq Neuropsiquiatr,2010,68:495-501. 被引量:1
  • 6Czernecki V,Pillon B,Houeto JL,et al.Motivation,reward,and Parkinson's disease:influence of dopatherapy.Neuropsychologia,2002,40:2257-2267. 被引量:1
  • 7Minguez-Castellanos A,Chamorro CE,Escamilla-Sevilla F,et al.Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?a cohort study.Neurology,2007,68:2012-2018. 被引量:1
  • 8Probst A,Bloch A,Tolnay M.New insights into the pathology of Parkinson's disease:does the peripheral autonomic system become central?Eur J Neurol,2008,15:1-4. 被引量:1
  • 9Hobson JA,Pace-Schott EF.The cognitive neuroscience of sleep:neuronal systems,consciousness and learning.Nat Rev Neurosci,2002,3:679-693. 被引量:1
  • 10Quelhas R,Costa M.Anxiety,depression,and quality of life in Parkinson's disease.J Neuropsychiatry Clin Neurosci,2009,21:413-419. 被引量:1

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