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基于倾向性评分匹配法的针刺戒烟随机对照研究与队列研究的疗效比较

Acupuncture for tobacco cessation: Comparison of treatment effects in randomized and cohort study based on propensity score matching
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摘要 目的:比较针刺戒烟的随机对照研究与队列研究的临床疗效差异,为进一步明确针刺戒烟的疗效提供循证医学证据。方法:分析针刺戒烟的随机对照研究(CATCR)与香港“中医针灸戒烟”队列研究的受试者信息,确定最小数据集,以8周戒烟成功率作为主要结局指标,采用SPSS 24.0软件对两项研究的受试者资料进行倾向性评分匹配(PSM)分析,得到组间协变量均衡的样本,并利用新样本进行疗效比较。结果:共100例CATCR研究的受试者和3 967例香港“中医针灸戒烟”研究的受试者纳入分析,并在性别、年龄、教育程度、吸烟特点等方面均存在统计学差异(P<0.05)。经PSM处理后,99对受试者匹配成功,且各基线变量均无统计学差异;队列研究8周戒烟率为34.34%,与CATCR的35.35%相比差异无统计学意义(OR=0.97,95%CI[0.56,1.68]);20个亚组人群中,仅5个亚组人群在两项研究中的戒烟成功率存在显著差异(P<0.05);队列研究复吸者的开始复吸时间为23.35d,与RCT的25.21d相比差异无统计学意义。结论:针刺戒烟的疗效与有效性相当,故而可以作为临床实际有效的戒烟方法进行推广使用。 Objective: To compare the clinical differences between randomized controlled study and cohort study of acupuncture for smoking cessation, and to provide evidence-based medical evidence for further clarifying the efficacy of acupuncture for smoking cessation. Methods: The information of subjects in the randomized controlled study and cohort study of acupuncture for smoking cessation were analyzed, and the minimum data set was determined. The success rate of smoking cessation in 8 weeks was taken as the main outcome index. PSM was performed by software SPSS 24.0, and the new data was obtained and compared. Results: A total of 100 subjects in RCT and 3 967 subjects in cohort study were included in the analysis, and there were statistical differences in gender, age, education level and smoking characteristics(P<0.05). After PSM, 99 pairs of subjects were successfully matched, and there was no statistical difference among the baseline variables;smoking cessation rate was 34.34% in 8 weeks of cohort study, and there was no significant difference compared with 35.35% of RCT(OR= 0.97, 95%CI[0.56, 1.68]);among 20 subgroups, only 5 subgroups had different quit rates(P<0.05). The time to relapse in cohort study was 23.35 days, and there was no significant difference compared with 25.21 days of RCT. Conclusion: The effectiveness and efficacy of acupuncture for smoking cessation was similar, so it can be used as a practical and effective method for quitting smoking in clinic.91070A 2019,(01):119-121.
作者 刘朝 杨金生 吴远 杨莉 柴欣 肖涛 陈敏 王莹莹 LIU Zhao;YANG Jin-sheng;WU Yuan;YANG Li;CHAI Xin;XIAO Tao;CHEN Min;WANG Ying-ying(Tobacco Medicine and Tobacco Cessation Centre, China-Japan Friendship Hospital, Beijing 100029, China;WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention, Beijing 100029, China;Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China;Hong Kong Pok Oi Hospital, Hong Kong, China)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2019年第1期114-119,共6页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 北京市中医药科技发展资金(No.JJ2018-97) 国家中医药行业科研专项基金(No.201307014).
关键词 针刺 戒烟 队列研究 随机对照研究 倾向性评分匹配 Acupuncture Smoking cessation Cohort study Randomized controlled study Propensity score match (PSM)
作者简介 通讯作者:王莹莹,北京市东城区东直门内南小街16号中国中医科学院针灸研究所,邮编:100700,电话:010-64089297.E-mail:yyw261206@126.com.
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