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40岁及以下年轻乳腺癌患者临床病理特征分析 被引量:5

The clinical and pathological characteristics of breast cancer in women ≤40 years of age
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摘要 目的 回顾性分析40岁及以下年轻乳腺癌患者的临床病理特征。方法收集2008年1月1日至2012年12月31日在解放军总医院就诊并获得明确病理诊断的原发性年轻女性(≤40岁)乳腺癌患者131例(年轻组),并采用随机数字表法随机抽取相同时期年龄在41~69岁的中老年乳腺癌患者262例(中老年组)进行对比分析,包括T分期、组织学分级、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(Her-2)的表达、临床分期等情况。结果与中老年组相比,年轻组乳腺癌激素受体表达水平较低(64.9%:76.7%;X2=6.171,P=0.013),Her-2表达水平较高(26.7%:15.3%;X2=7.415,P=0.006),具有更高的组织学分级(Ⅱ级38.2%:35.1%;Ⅲ级55.7%:49.6%;X2=6.835,P=0.033)。两组患者在T分期(X2=1.764,P=0.623)、N分期(X2=0.129,P=0.988)、临床分期(矿=4.916,P=0.178)、分子分型(X2=7.475,P=0.058)、手术方式(X2=0.913,P=0.339)方面的差异无统计学意义。结论年轻乳腺癌患者有其特殊的临床病理特点,组织学分级和Her-2表达水平均较年长者高,而激素受体表达水平相对较低,恶性程度更高,应早诊断、早治疗。 Objective To retrospectively analyze the clinical and pathological characteristics of breast cancer in women ≤40 years of age. Methods One hundred and thirty one young ( ≤ 40 years ) female patients with breast cancer pathologically confirmed in the General Hospital of PLA from January 1 st 2008 to December 31 st 2012 ( young group) were collected, and 262 elderly ( 41-69 years) female patients with breast cancer in the same period (old group) were eollected as eontrol using the random number table method. The elinicopathologieal characteristics involved TNM staging, histological grade, the expression levels of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor reeeptor-2 (Her-2) and clinical stage of the two groups were contrastively analyzed. Results Compared with elderly patients, young female patients with breast cancer had lower positive rate of E R or PR (64.9 % vs. 76.7 % ; )(2 = 6.171, P = 0. 013 ), X2 higher positive rate of Her-2 ( 26.7% vs. 15.3% ; = 7. 415, P =0. 006 ) and higher histological grade (grade ]] 38.2% vs. 35.1% ; grade III 55.7% vs. 49.6% ; X2 = 6. 835, P = 0. 033). There were no significant differences in T stage (X2 = 1. 764, P = 0. 623 ), N stage (X2 = 0. 129, P = 0. 988 ), clinical stage (X2 = 4. 916, P = 0. 178 ), molecular subtype (X2 = 7. 475, P =0. 058) and different surgical procedures (X2 = 0. 913, P =0. 339) between the two groups. Conclusion Young (≤40 years) female patients with breast cancer have specific clinical and pathological characteristics including higher histological grade, higher positive rate of Her-2, lower positive rate of ER or PR and higher degree of malignancy, who should be diagnosed and treated as soon as possible.
作者 徐虎 张昉 寇德强 王建东 Xu Hu Zhang Fang, Kou Deqiang, Wang Jiandong.( Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China)
出处 《国际肿瘤学杂志》 CAS 2016年第4期250-253,共4页 Journal of International Oncology
关键词 乳腺肿瘤 病理学 临床 Breast neoplasms Pathology, clinical
作者简介 通信作者:王建东,Email:vicky1968@163.com
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