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磷酸奥司他韦颗粒联合小儿氨酚黄那敏颗粒治疗小儿季节性流感的效果 预览 被引量:16

Effect of Oseltamivir Phosphate Granules combined with Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules for children with seasonal influenza
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摘要 目的探讨磷酸奥司他韦颗粒和小儿氨酚黄那敏颗粒联合治疗对小儿季节性流感的临床效果及安全性。方法将2015年9~12月航空总医院儿科收治的季节性流感患儿86例作为研究对象,随机分为对照组和观察组,每组各43例。根据患儿的体重给予对照组患儿磷酸奥司他韦颗粒,2次/d,连续服用5 d;根据患儿的体重给予观察组患儿不同剂量小儿氨酚黄那敏颗粒,3次/d,连续服用3 d,同时联合应用磷酸奥司他韦颗粒,磷酸奥司他韦颗粒的剂量和用法与对照组相同。比较两组患儿的临床有效率、退热时间、咳嗽消失时间、咽痛消失时间、疲倦缓解时间、总症状积分,以及不良反应发生情况。结果观察组患儿治疗的临床总有效率较对照组明显提高(P〈0.05);观察组患儿退热时间、咳嗽消失时间、咽痛消失时间、疲倦缓解时间较对照组明显缩短(P〈0.05);观察组患儿治疗后总症状积分明显少于对照组(P〈0.05);观察组患儿治疗后肺炎发生率明显低于对照组(P〈0.05);治疗前后两组患儿均未出现严重不良反应。结论磷酸奥司他韦颗粒联合小儿氨酚黄那敏颗粒可明显缓解小儿季节性流感患儿的临床症状,并防止高热惊厥和肺炎的发生,减少并发症的发生,安全性较高,建议推广。 Objective To explore the clinical effect and safety of Oseltamivir Phosphate Granules combined with Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules in the treatment of children with seasonal influenza. Methods 86 children with seasonal influenza from September to December 2015 in Aviation General Hospital were randomly divided into 43 cases of the control group and 43 cases of the observation group randomly. All children were given routine examination after admission; the control group was treated with different dose of Oseltamivir phosphate granule to take orally according to the weight of children, twice daily, for 5 days. The observation group was treated with Oseltamivir Phosphate Granules combined with Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules, the dosage and usage of Oseltamivir Phosphate Granules was as the same as the control group, Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules was 3 times daily, for 3 days.The clinical efficiency, defervescence time, disappearance time of cough, disappearance time of sore throat, fatigue remission time, total symptom score, and the incidence condition of adverse reaction of children in the two groups were compared. Results The total clinical efficiency in the observation group was significantly higher than that in the control group(P 0.05); defervescence time, disappearance time of cough, disappearance time of sore throat, fatigue remission time in the observation group was shorter than those in the control group(P 0.05); total symptom score after treatment in the observation group was significantly less than that in the control group(P 0.05); the incidence of pneumonia in the observation group after treatment was significantly lower than that in the control group(P 0.05); there was no serious adverse reaction in the two groups before and after treatment. Conclusion Oseltamivir Phosphate Granules combined with Pediatric Paracetamol Atificial Cow-bezoar and
作者 杨立新 YA NG Lixin (Department of Pediatrics, Aviation General Hospital of China, Beijing 100012, China)
机构地区 航空总医院儿科
出处 《中国医药导报》 CAS 2016年第15期120-123,共4页 China Medical Herald
关键词 磷酸奥司他韦 小儿氨酚黄那敏颗粒 季节性流感 咳嗽 Oseltamivir Phosphate Granule Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules Seasonal influenza Cough
作者简介 杨立新(1966.10-),女,湖北来峰人,副主任医师:研究方向:临床儿科。
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