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药物涂层球囊治疗周围动脉疾病的循证医学证据 被引量:6

Drug-coated balloon for peripheral artery diseases:current evidence-based data
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摘要 药物涂层球囊(DCB)为治疗周围动脉疾病提供了新的策略,国际上已对其有效性开展了诸多对照研究,其中更多集中在对股腘动脉病变的治疗方面。相对于普通球囊,DCB能够减少股腘动脉TASC-A/B级病变术后6个月甚至1年内的晚期管腔缺失和再狭窄率,减少二次干预率,而其中、远期结果,而且在处理TASC-C/D级病变中的效果尚缺少充分的研究报道。关于DCB治疗膝下动脉病变的临床对照研究相对较少,而且与普通球囊的对比结果也并不一致。因此亟待高证据级别的临床随机对照试验来回答这些问题。 Drug-coated balloon (DCB) provides a new treatment strategy for peripheral artery diseases (PAD) and its effectiveness has been tested in several controlled studies in different countries, most of which focused on its use in femoropopliteal leisons. Compared with uncoated balloon, DCB can reduce late lumen loss and restenosis of femoropopliteal TASC-A/B lesions at 6 months and even 1 year after operation and decrease the re-intervention rate, but there is a lack of its mid-and long-term follow-up results as well as its efficacy for TASC-C/D lesions. Studies on using DCB in treatment of infra-popliteal diseases are relatively scarce, in which even more unfortunately, the results are not consistent with each other in terms of comparison between DCB and uncoated balloon. Thus, more high-quality well-controlled studies are urgently needed to answer these questions.
作者 郭伟 卫任 GUO Wei, WEI Ren (Department of Vascular Surgery, Chinese PLA General Hospital, Beijing 100853, China)
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2016年第6期785-789,共5页 Chinese Journal of General Surgery
关键词 外周动脉疾病 下肢 药物涂层球囊 循证医学 Peripheral Artery Disease Lower Extremity Drug-Coated Balloon Evidence-Based Medicine
作者简介 专家介绍:郭伟,中国人民解放军总医院血管外科/全军血管外科中心主任、教授,解放军医学院、清华大学、南开大学博士生(后)导师。长期从事血管疾病的临床、科研、教学和保健工作。中央保健委员会会诊专家、中华医学会血管外科及生物工程分会副主任委员、中国医师学会血管外科分会副主任委员、海峡两岸医药卫生交流协会血管外科专家委员会副主任委员、中国医疗保健国际交流促进会血管外科专业委员会副主任委员、中国老年医学学会血管专业委员会副主任委员、科技部科研课题评审专家、北京市医学事故鉴定委员会专家。军队高科技拔尖人才和科技新星。美国《Journal of Endovascular therapy》杂志、美国《Annal vascular sugery》杂志、《Journal of Chinese Medicine》、《中华医学杂志》、《中华外科杂志》、《中华生物医学工程杂志》、《中华普通外科杂志》、《中华老年医学杂志》等10余种杂志编委。近年来发表论著210余篇,其中多篇论文分别发表在《Journal of Vascular Surgery》,《EuropeanJournal of Vascularand Endovascular Surgerv》等国际著名杂志上。主编《腔内血管外科学》、《主动脉瘤及夹层的腔内修复术》、《血管疾病腔内治疗系列手术》。主译《血管和腔内血管外科学精要》、《卢瑟福血管外科学》。参编著作8部。获国家专利12项,国家及省部级课题1l项;国家科技进步一等奖1项、北京市科技成果一等奖1项、军队医疗成果一等奖1项、军队医疗成果二等奖1项。主要贡献:自1997年以来率先在国内开展腹主动脉瘤、主动脉夹层、胸主动脉瘤的腔内修复术;率先开展复杂主动脉瘤与夹层的杂交手术;周围动脉狭窄或闭塞的腔内和杂交手术治疗等。2008年以来连续6年应邀为著名LINC大会(德国)手术直播,为南美CICE大会做现场手术直播
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