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小金片联合沙利度胺治疗晚期消化道肿瘤患者的临床观察 被引量:1

The Observation on the Effect of Thalidomide Combined with Xiaojin Tablets in the Treatment of Advanced Digestive Tract Cancer
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摘要 目的:观察小金片联合沙利度胺对晚期消化道肿瘤患者的疗效及毒副反应和免疫功能的影响。方法:33例晚期消化道肿瘤患者,均口服小金片1.08g,2次/d;沙利度胺100mg,1次/qn。60d后观察疗效和毒副反应,同时于治疗前1d,治疗后60d测定其外周血T淋巴细胞亚群,观察免疫功能的变化,结果:总有效率18%(CR+PR),CR0例,PR6例,SD10例,临床收益率48%,主要不良反应为:乏力,头晕,嗜睡,麻木,恶心,感觉异常等。治疗前患者外周血CD3+T细胞,CD4+T细胞低,CD4/CD8+比值低,CD8+T细胞高,治疗后外周血CD3+、CD4+及CD4+/CD8+细胞比值较治疗前升高明显,CD8+T细胞降低明显(P〈0.05),差异有统计学意义。结论:晚期消化道肿瘤患者免疫功能低下,小金片联合沙利度胺治疗可改善晚期消化道肿瘤患者机体免疫功能,疗效肯定,毒副反应可以耐受。 Objective: To observe the efficacy and toxicity with the changes of immune function of thalidomide combined with Xiaojin tablets in the treatment of patient with advanced digestive tract cancer. Methods: 33 patients with advanced digestive tract cancer were treated with thalidomide (100mg dl) and Xiaojin tablets (1.08Bid) the efficacy and toxicity were evaluated after treatment of 60 days; the number of T lymphocyte subsets( CD3+; CD4+; CD8+) of all patients were examined in blood samples at 1 day before treatment and after 60 days of treatment.Observe the changes of immune function. Results: The total efficiency was (CR+PR)18%; CR 0 case; PR 6 cases; SD 10 cases; the clinical efficiency was 48%; Main adverse reactions are: fatigue; dizziness; drowsiness; numb; nausea; paresthesia; etc. Num- bers of T lymphocyte subsets( CD3+; CD4+; CD4+/CDS+) of patients after treatment were significantly increased than those before treatment while CD8+T lymphocyte number was significantly declined . There were significant differences between the numbers of CD3+; CD4+; CD8+T cells and CD4+/CD8+ ratio before and after treatment .Conclusion: The immune function in patients with advanced digestive tract cancer is suppressed and may be improved by thalidomide combined with Xiaojin tablets; the curative effect affirmed; and the toxicity can be tolerated.
作者 廖湘晖 官成浓 LIAO Xianghui,GUAN Chengnong(Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524000, China)
出处 《中医药临床杂志》 2016年第6期830-832,共3页 Clinical journal of traditional chinese medicine
关键词 小金片 沙利度胺 晚期消化道肿瘤 免疫功能 Xiaojin tablets thalidomide advanced digestive tract cancer immunologic function
作者简介 廖湘晖为广东暨南大学2011年在读博士。 通讯作者:官成浓(1967-),男,博士,主任医师。研究方向:消化肿瘤。E-mail:guangchengnong@163.com
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