期刊文献+

Gelsolin的生物学功能与其在疾病诊断及治疗中的作用

The role and function of gelsion in disease diagnosis and treating
分享 导出
摘要 凝溶胶蛋白(Gelsolin)是一种激动蛋白结合蛋白,目前被认为在细胞运动、细胞吞噬中有重要的作用.近年,研究表明在许多疾病中血清Gelsolin水平下降,且其与疾病的严重程度、并发症的发生率和并发症的严重程度有关,能够预测并发症的发生和严重程度.Gelsolin还被发现有降糖和抗炎的作用,可以对疾病治疗起到一定作用.因而有必要对Gelsolin的生物学功能与其在疾病诊断及治疗中的作用进行研究. Gelsolin is a kind of actin binding protein and plays an important role in cell migration and phagocytosis.Recentlly,the decreasing level of gelsolin has been reported in many diseases.It has correlation with the severity of disease and complications.Gelsolin can be used in the treatment of some diseases such as type Ⅱ diebetes and pneumonia.
作者 孙迪 李辉 考文萍 张凤民 Department of Microbiology Harbin Medical University, Wu Lien-Teh Institute ,Heilongfiang Provincial Key Labo- ratory for Infection and Immunity, Key Laboratory of Pathogenic Biology Heilon~iang Higher Education Institu- tions Harbin 150081 ,China( Sun D,Kao WP,Zhang FM ) College of Basic Medicine Harbin Medical University Harbin 150081, China( Li H)
出处 《国际免疫学杂志》 CAS 2016年第4期364-367,共4页 International Journal of Immunology
基金 基金项目:国家863目标导向项目(2006AA022481) 黑龙江省博士后科研启动资金(LBH-Q14106)
关键词 凝溶胶蛋白 诊断 治疗 Gelsolin Diagnosis Treatment
作者简介 通信作者:张凤民,Email:fengminzhang@ems.hrbmu.edu.cn
  • 相关文献

参考文献18

  • 1Yin HL, Stossel TP. Control of cytoplasmic actin gel-sol transforma- tion by gelsolin, a calcium-dependent regulatory protein [ J ]. Na- ture, 1979,281 (5732) :583-586. 被引量:1
  • 2Vouyiouklis DA, Brophy PJ. A novel gelsolin isoform expressed by oligodendrocytes in the central nervous system [ J ]. J Neurochem, 1997,69(3) :995-1005. 被引量:1
  • 3Bucki R, Byficld FJ, Kulakowska A, et al. Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proin- flammatory bacterial wall components [ J ]. J Immunol, 2008,181(7) :4936-4944. DOI : 10. 4049/jimmunol. 181.7. 4936. 被引量:1
  • 4Wang H, Cheng B, Chen Q, et al. Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patiefits [ J ]. Crit Care ,2008,12 (4) : R106. DOI : 10.1186/cc6988. 被引量:1
  • 5Hu Y, Li H, Li WH, et al. The value of decreased plasma gelsolin levels in patients with systemic lupus erythematosus and rheuma- toid arthritis in diagnosis and disease activity evaluation [ J ]. Lu- pus, 2013, 22 ( 14 ) : 1455-1461. DOI: 10. 1177/ 0961203313507985. 被引量:1
  • 6Han C, Zhang L, Zhu X, et al. Plasma gelsolin levels are decreased and correlate with fibrosis in IgA nephropathy[ J] .Exp Biol Med (Maywood), 2013, 238 (11): 1318-1327. DOI: 10. 1177/ 1535370213503256. 被引量:1
  • 7Argun M, Baykan A, Narin F, et al. Plasma gelsolin as a biomarker of acute rheumatic carditis [ J ]. Cardiol Young, 2015,25 ( 7 ) : 1276-1280. DOI : 10. 1017/S1047951114002327. 被引量:1
  • 8Yang Z, Chiou TT, Stossel TP, et al. Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function[J]. Am J Physiol Lung Cell Mol Physiol,2015,309( 1 ) : L11-16. DOI : 10.1152/ajplung. 00094. 2015. 被引量:1
  • 9Shi S, Chen C, Zhao D, et al. The role of plasma gelsolin in car- diopulmonary bypass induced acute lung injury in infants and young children : a pilot study[ J]. BMC Anesthesiol,2014 ,14 :67. DOI: 10. 1186/1471-2253-14-67. 被引量:1
  • 10McLaughlin PJ, Gooch JT, Mannherz HG, et al. Structure of gelso- lin segment 1-actin complex and the mechanism of filament seve- ring[ J ]. Nature, 1993,364 ( 6439 ) : 685-692. DOI : 10. 1038/ 364685a0. 被引量:1
投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈