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益肾骨康膏治疗肾虚血瘀型癌性躯体痛的临床研究 被引量:15

Therapeutic Effects of Yishen Gukang Ointment in Treatment of Kidney Deficiency and Blood Stasis Type of Somatic Cancer Pain
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摘要 目的:通过规范化的临床研究验证中药益肾骨康膏外敷治疗肾虚血瘀型癌性躯体痛的有效性和安全性。方法:本研究采用随机、对照前瞻性临床试验方法,将符合方案69例中重度癌性躯体痛患者随机分为试验组(n=35)和对照组(n=34),对照组给予盐酸羟考酮治疗癌性疼痛,治疗组在盐酸羟考酮基础治疗之上给予益肾骨康膏外敷痛处,通过1个疗程共计10 d的观察期,通过对治疗前后NRS评分、疼痛影响评分、体力状况等关键指标的对比,评价益肾骨康膏治疗癌性躯体痛的有效性和安全性。结果:益肾骨康膏试验组的总有效率为94.3%,显效率为85.6%,与对照组(总有效率84.3%,显效率58.9%)相比,有统计学差异(P=0.013,P〈0.05)。疼痛影响评分较治疗前降低(治疗前40.23±12.533,治疗后23.77±12.386,P〈0.05),与对照组比较均具有统计学意义(P=0.039,P〈0.05);试验组患者治疗期间平均爆发痛次数较对照组少(试验组0.77±0.424,对照组1.22±0.726,P=0.002,P〈0.01);试验组KPS评分改善优于对照组(试验组70.00±15.339,对照组62.94±11.685,P=0.036,P〈0.05);治疗过程中及治疗前后,患者未出现明显皮肤不良反应,安全性指标检查较前无明显变化。结论:益肾骨康膏治疗肾虚血瘀型癌性躯体痛疗效确切,能够改善患者生活质量,而且安全性好,值得进一步深入研究、推广。 Objective: To study the efficacy and safety of Yishen Gukang Ointment on relieving the somatic cancer pain of kidney deficiency and blood stasis pattern. Methods: In this study,a randomized,controlled prospective clinical trial was designed. A total number of 69 patients with moderate to severe pain were randomly divided into treatment group( n = 39) and control group( n = 34),both of which were given opioids analgesic therapy. On this basis,the treatment group was externally treated with Yishen Gukang Ointment. The therapeutic course lasted for 10 days. Before and after the treatments,such indices as NRS pain scores,Karnofsky scores,grade in impact of pain measurement and so on were compared with each other,and their clinical therapeutic results were evaluated. Results: Compared with the control group( total efficiency 84. 3%,significant efficiency58. 9%),the total efficiency of the treatment was 94. 3%,and the significant efficiency was 85. 6%,which shows significant difference between these two groups( P = 0. 013,P〈0. 05). After the treatment,the NRS pain scores decreased remarkably in the treatment group( betoretreatment: 5. 1 ± 1. 471,after treatment: 1. 86 ± 1. 700,P〈0. 05),so as to the grade in impact of pain measurement( before treatment: 40. 23 ± 12. 533,after treatment: 23. 77 ± 12. 386,P〈0. 05),both of which show significant difference compared with the control group( P = 0. 039,P〈0. 05). The mean occurrence of breakthrough pain of the treatment group was less than control group( 0. 77 ± 0. 424VS1. 22 ± 0. 726,P = 0. 002,P〈0. 01),and the Karnofsky scores were significantly better( 70. 00 ± 15.339VS62. 94 ± 11. 685,P = 0. 036,P〈0. 05). No adverse reaction like skin allergy was found during the treatment. Conclusion:Yishen Gukang Ointment is effective in relieving the somatic cancer pain of patients with the kidney deficiency and blood stasis pattern,which can better improve the quality of life and deserve to be applied because of it
作者 芦殿荣 芦殿香 柏大鹏 何生奇 王芳 高音 杜艳林 江正龙 冯利 LU Dianrong ,LU Dianxiang ,BAI Dapeng , HE Shengqi ,WANG Fang , GAO Yin , DU Yanlin ,JIANG Zhenglong , FENG Li ( 1. Oncology of Wangjing Hospital, China Academy of Chinese Medical Sciences,Beijing 100102, China; 2. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, Qinghai, China; 3. Oncology of Fangshan Hospital of Traditional Chinese medicine, Beijing 100029, China)
出处 《辽宁中医杂志》 CAS 北大核心 2016年第7期1402-1407,共6页 Liaoning Journal of Traditional Chinese Medicine
基金 中国中医科学院望京医院资助项目(WJYYYNZJZJ2X2012XX) 北京市科委“首都特色专项北京市科委”首都特色专项(141107002514045)
关键词 癌性疼痛 益肾固康膏 肾虚血瘀 中医外治 Cancer Pain Yishen Gukang Ointment Kidney Deficiency and Blood Stasis Pattern External Treatment of TCM
作者简介 作者简介:芦殿荣(1978-),女,甘肃永昌人,副主任医师,博士,研究方向:中医药抗肿瘤临床及基础研究。 通讯作者:冯利(1967-),男,主任医师,博士后,研究方向:中医药抗肿瘤临床及基础研究,E-Mail:fengli663@126.com。
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