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肿瘤相关抗原及其自身抗体在肝细胞癌早期诊断中的应用 预览 被引量:1

Application of tumor-associated antigens and their autoantibodies in early diagnosis of hepatocellular carcinoma
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摘要 肝细胞癌(HCC)的早期发现、早期诊断是提高HCC患者生存率的必要手段。研究发现,一种由肿瘤细胞释放的异常蛋白即肿瘤相关抗原刺激产生的自身抗体在HCC患者临床诊断前就已存在,因此可能成为HCC早期诊断的新型潜在标志物。简述了几种新型肿瘤相关抗原抗体在HCC诊断中的应用现状,认为肿瘤相关抗原抗体在HCC诊断中具有较大的前景及临床应用价值。 Early identification and diagnosis of hepatocellular carcinoma( HCC) is necessary for improving survival rates of HCC patients.Studies have shown that the abnormal proteins released by tumor cells,i. e.,the autoantibodies stimulated by tumor- associated antigens( TAAs),can be detected before a clinical diagnosis of HCC is made,and therefore,such proteins may become the new markers for the early diagnosis of HCC. This article reviews the application of several new autoantibodies to tumor- associated antigens in the diagnosis of HCC and points out that these autoantibodies have promising prospects and clinical significance in the early diagnosis of HCC.
作者 王婷 刘梅 董蕾 段钟平 WANG Ting, LIU Mei, DONG Lei, et al. (Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China)
出处 《临床肝胆病杂志》 CAS 2016年第7期1418-1421,共4页 Chinese Journal of Clinical Hepatology
基金 首都医科大学基础-临床科研合作基金(15JL67) 北京卫生系统高技术人才培养项目基金(2015-3-104) 北京市教委科技计划面上项目(2015) 国家十二五科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”(2012ZX10002004-006,2012ZX10004904-003-001,2013ZX10002002-006)
关键词 肝细胞 抗原 肿瘤 抗体 肿瘤 早期诊断 综述 carcinoma hepatocellular antigens neoplasm antibodies neoplasm early diagnosis review
作者简介 王婷(1989-),女,博士,主要从事肝癌诊断及肝衰竭的研究 通信作者:段钟平,电子信箱:duan2517@163.com。
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