期刊文献+

不同化疗方案联合热疗在Ⅲ、Ⅳ期肺癌中的临床疗效分析 预览 被引量:1

Clinical Curative Effect Analysis of Different Chemotherapy Regimens Combined with Hyperthermia in the Treatment of Stage Ⅲ and Ⅳ Lung Cancer
在线阅读 下载PDF
收藏 分享 导出
摘要 目的:探讨分析不同化疗方案联合热疗在Ⅲ、Ⅳ期肺癌中的临床疗效,并比较其治疗安全性。方法:选取2012年3月-2014年5月本院收治的肺癌患者103例作为研究对象,随机分为研究组50例和对照组53例。研究组给予培美曲塞+洛铂+局部热疗方案,对照组给予培美曲塞+顺铂+局部热疗方案,比较分析两组临床疗效和安全性。结果:研究组治疗总有效率68.0%,高于对照组的45.3%,比较差异有统计学意义(P〈0.05);两组患者1年生存率比较差异无统计学意义(P〉0.05);治疗期间研究组各类毒副反应发生率均低于对照组,比较差异均有统计学意义(P〈0.05)。结论:含洛铂化疗方案联合热疗可有效提高短期治疗效果,显著降低毒副反应,但远期疗效与含顺铂方案无显著差异。 Objective:To investigate the clinical effect of different chemotherapy regimens combined with hyperthermia in the treatment of stageⅢ andⅣ lung cancer,and compare the safety of the treatment. Method:From March 2012 to May 2014,103 cases of lung cancer in our hospital were selected as the research objects,they were randomly divided into 50 cases of the study group and 53 cases of the control group.The study group was given Pemetrexed,Lobaplatin and local hyperthermia,the control group was given Pemetrexed, Cisplatin and local hyperthermia,the clinical efficacy and safety of the two groups were compared and analyzed.Result:The total effective rate of the study group was 68.0%,which was higher than 45.3% of the control group,the difference was statistically significant(P〈0.05).There was no significant difference in the 1 year survival rate of two groups(P〉0.05).During the treatment period,the incidence of all kinds of toxic and side effects in the study group was lower than the control group,the differences were statistically significant (P〈0.05).Conclusion:Lobaplatin chemotherapy regimens combination local hyperthermia can effectively improve short-term therapeutic effect and significantly reduce the toxicity,but the long-term effect is no significant difference with the cisplatin regimen.
作者 闫俊丽 贺会江 YAN Jun-li, HE Hui-jiang(The PLA 150 Central Hospital, Luoyang 471003, China)
出处 《中国医学创新》 CAS 2016年第23期121-124,共4页 Medical Innovation of China
关键词 肺癌 化疗 热疗 洛铂 顺铂 Lung cancer Chemotherapy Hyperthermia Lobaplatin Cisplatin
作者简介 通信作者:闫俊丽
  • 相关文献

参考文献20

二级参考文献145

共引文献66

同被引文献14

引证文献1

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈
新型冠状病毒肺炎防控与诊疗专栏