期刊文献+

中性粒细胞和淋巴细胞比率与急性心肌梗死患者心室重构及预后的相关性 预览 被引量:2

Relationship between neutrophil/lymphocyte ratio and ventricular remodeling and prognosis in patients with acute myocardial infarction
在线阅读 下载PDF
收藏 分享 导出
摘要 目的:探讨急性心肌梗死(AMI)患者血液中性粒细胞和淋巴细胞比率(NLR)与心室重构及预后的关系。方法:选取2012年4月~2014年4月入院的105例AMI患者,40例健康体检者为对照组,检测各组血液NLR值。给予患者静脉溶栓及延期PCI术治疗。分别于溶栓后1周及PCI术后6个月采用超声心动图测量并计算左室舒张末期容积指数(LVEDVI),计算△LVEDVI值,根据其值≥20%与否分为AMI伴心室重构(VR),观察AMI患者主要心血管不良事件(MACE)的发生率。结果:AMI伴心室重构(VR组)40例,不伴心室重构(NVR)组65例。NVR组和VR组血液NLR值均显著高于对照组(P〈0.01);VR组血液NLR值显著高于NVR组(P〈0.01);多因素Logistic回归分析结果,血液NLR值是AMI心室重构的独立危险因素(OR=9.92,P〈0.01);VR组MACE发生率显著高于NVR组(P〈0.01)。结论:AMI患者血液NLR值与心室重构及预后相关。 Objective:To investigate the relationship between value of neutrophil/lymphocyte ratio(NLR)and ventricular remodeling and prognosis in patients with acute myocardial infarction(AMI).Methods:One hundred and five patients with AMI who hospitalized from April 2012 to April 2014(AMI group)and 40 cases of healthy people(CON)were included.The peripheral blood neutrophil leucocytes and lymphocytes were measured prior to intervention and NLR was calculated.Patients were treated with intravenous thrombolysis and percutaneous coronary intervention(PCI).One week after intravenous thrombolysis and 6 months after PCI,echocardiography was used to measure left ventricular end diastolic volume index(LVEDVI).The change of LVEDVI(△LVEDVI) was used to define ventricular remodeling with cut-off value 20%.The incidence of major adverse cardiovascular event(MACE)was recorded.Results:Forty cases of AMI had ventricular remodeling(VR group)and 65 cases did not have VR(NVR group).The value of NLR in the two groups were significantly higher than that in CON group(P〈0.01).It was significantly higher in VR group than in NVR group(P〈0.01).Multivariate logistic regression analysis showed that NLR was an independent risk factor for ventricular remodeling in patients with AMI(P〈0.01).The incidence of MACE in VR group were significantly higher than NVR group(P〈0.01).Conclusion:A higher value of NLR was associated with ventricular remodeling.
作者 李宾 刘静 刘姝莉 黄俊 葛雄 甘受益 LI Bin,LIU Jing,LIU Shu-li,et al ( Department of Cardiology,Xianning Central Hospital,The First Affiliated Hospital of Hubei University of Science and Technology,Xianning 437100,Hubei,China)
出处 《中日友好医院学报》 2016年第4期225-228,232共5页 Journal of China-Japan Friendship Hospital
关键词 急性心肌梗死 中性粒细胞和淋巴细胞比率 心室重构 主要心血管不良事件 acute myocardial infarction neutrophil/lymphocyte ratio ventricular remodeling major adverse cardiovascular event
作者简介 李宾(1982-),男,主治医师,医学硕士。 本文通讯作者。
  • 相关文献

参考文献19

  • 1Jin J,Wang H,Song YM,et al.Clinical outcome and left ventricular remodeling in AMI patients with insufficient myocardial reperfusion after recanalization[J].Clin Invest Med,2010,33(5):E304-312. 被引量:1
  • 2van Diepen S,Roe MT,Lopes RD,et al.Baseline NT-pro BNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction:insights from the APEX-AMI trial[J].J Thromb Thrombolysis,2012,34(1):106-113. 被引量:1
  • 3Cui M,Jing R,Fan M,et al.The relationship between cellfree circulating DNA and inflammation in acute coronary syndrome[J].Cardiology,2013,126(2):124-125. 被引量:1
  • 4Pearson TA,Mensah GA,Alexander RW,et al.Markers of inflammation and cardiovascular disease:application to clinical and public health practice:A statement for healthcare professionals from the centers for disease control and prevention and the american heart association[J].Circulation,2003,107(3):499-511. 被引量:1
  • 5Tanlndl A,Erkan AF,Ekici B,et al.Neutrophil to lymphocyte ratio is associated with more extensive,severe and complex coronary artery disease and impaired myocardial perfusion[J].Turk Kardiyol Dern Ars,2014,42(2):125-130. 被引量:1
  • 6Papa A,Emdin M,Passino C,et al.Predictive value of elevated neutrophil lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease[J].Clin Chim Acta,2008,395(1-2):27-31. 被引量:1
  • 7Bettencourt P,Ferreira A,Pardal-Oliveira N,et al.Clinical significance of brain natriuretic peptide in patients with postmyocardial infarction[J].Clin Cardiol,2010,23(12):921. 被引量:1
  • 8O’Gara PT,Kushner FG,Ascheim DD,et al.2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines[J].Circulation,2013,127(4):e362-e425. 被引量:1
  • 9Distelmaier K,Winter MP,Dragschitz F,et al.Prognostic value of culprit site Neutrophils in acute coronary syndrome[J].Eur J Clin Invest,2014,44(3):257-265. 被引量:1
  • 10Keresztes M,Horváth T,Ocsovszki I,et al.ACTH and cortisol-associated Neutrophil modulation in coronary artery disease patients undergoing stent implantation[J].PLo S One,2013,8(8):e71902. 被引量:1

二级参考文献54

  • 1Libby P. Inflammation in atherosclerosis [J]. Nature, 2002,420 (6917) : 868-874. 被引量:1
  • 2Balta S, Demirkol S, Celik T, et al. Association between coronary artery ectasia and neutrophil-lymphocyte ratio [J] . Angiology ,2013 ,64(8) :627-632. 被引量:1
  • 3Soylu K, Yuksel S, Gulel 0, et aI. The relationship of coronary flow to neutrophil!lymphocyte ratio in patients undergoing primary percutaneous coronary intervention [J]. J Thorac Dis, 2013 , 5 (3) :258-264. 被引量:1
  • 4Ghaffari S, Nadiri M, Pourafkari L, et aI. The predictive Value of Total Neutrophil Count and Neutrophil!Lymphocyte Ratio in Predicting In-hospital Mortality and Complications after STEMI [J]. J Cardiovasc Thorac Res,2014,6(1) :3541. 被引量:1
  • 5Shen XH, Chen Q, Shi Y, et al. Association of neutrophil! lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention [J]. Chin Med J (Engl) , 2010, 123 ( 23 ) : 3438- 3443. 被引量:1
  • 6Han YC, Yang TH, Kim DI, et aI. Neutrophil to Lymphocyte Ratio Predicts Long-Term Clinical Outcomes in Patients with STSegment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention [J]. Korean Circ J, 2013 ,43 (2):93-99. 被引量:1
  • 7Kaya MG, Akpek M, Lam YY, et al. Prognostic value of neutrophil!lymphocyte ratio in patients with ST -elevated myocardial infarction undergoing primary coronary intervention: a prospective ,multicenter study [J]. Int J Cardiol,2013 ,168(2) : 1154-1159. 被引量:1
  • 8Akpek M, Kaya MG, Lam YY, et al. Relation of neutrophil! lymphocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST -elevated myocardial infarction undergoing primary coronary intervention [J]. Am J Cardiol, 2012,110 (5) :621-627. 被引量:1
  • 9Sen N, Afsar B, Ozcan F, et aI. The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST -elevated myocardial infarction undergoing primary coronary intervention [J]. Atherosclerosis ,2013 ,228 ( I ) :203-210. 被引量:1
  • 10Nunez J, Nunez E, Bod! V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction [J]. Am J Cardiol, 2008, 101 (6) :747-752. 被引量:1

共引文献13

同被引文献9

引证文献2

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈