期刊文献+

紫杉醇药物涂层球囊治疗症状性下肢动脉硬化闭塞症的早中期结果 被引量:5

Drug coated balloon with paclitaxel for the treatment of symptomatic peripheral artery disease: early and midterm results
收藏 分享 导出
摘要 目的评估紫杉醇药物涂层球囊治疗症状性下肢动脉硬化性闭塞症的有效性和安全性。方法对解放军总医院血管外科2013年10月至2014年6月应用紫杉醇药物涂层球囊(DCB)诊治的18例下肢动脉硬化闭塞症患者的临床数据进行回顾分析。18例患者中,男性13例,女性5例,平均年龄(65±7)岁,卢瑟福分级为3-5级。术后3、6个月进行随访,主要随访项目为晚期管腔丢失、靶病变再狭窄率、临床驱动的靶病变再次血运重建率(TLR),以及围手术期及术后6个月的严重临床事件。结果纳入研究的病变平均长度为(138±91) mm,慢性闭塞性病变所占比例为9/18,支架内再狭窄比例为2/18。手术技术成功比例为18/18。术后6个月,晚期管腔丢失为(0.1±0.9) mm,靶病变再狭窄比例为2/14,临床驱动的靶病变再次血运重建率为0。未发生死亡和截肢等严重不良事件。结论紫杉醇DCB在治疗下肢动脉硬化性闭塞症方面安全性可靠,能降低术后6个月的远期管腔丢失、再狭窄率和临床驱动的靶病变再次血运重建率。 Objective To evaluate the safety and efficacy of the drug coated balloon (DCB) with paclitaxel in patients with symptomatic peripheral artery disease (PAD).MethodsThe clinical data of 18 patients, who were diagnosed as PAD and treated with DCB from October 2013 to June 2014 in Department of Vascular Surgery, People's Liberation Army General Hospital, were retrospectively analyzed.Thirteen male and 5 female patients were in the series, the mean age of the patients was (65±7) years, and the Rutherford's categories were level 3 to 5. Patients were followed up at 3- and 6-month postoperative. The main efficacy end point were late lumen loss(LLL), rate of restenosis and clinically driven target lesion revascularization (TLR). Meanwhile, the clinical events were recorded.ResultsMean lesion length, the percentage of total occlusions and the percentage of in-stent restenosis were (138±91) mm, 9/18 and 2/18, respectively. Rate of technical success was 18/18. At 6-month postoperative, LLL, rate of restenosis and TLR were (0.1±0.9) mm, 2/14 and 0, respectively. There was no deaths or no amputations. ConclusionDCB with paclitaxel is safe in patients with PAD, and associated with reductions in LLL, restenosis and clinically driven TLR 6-month postoperative.
作者 许永乐 贾鑫 郭伟 刘小平 杜昕 孙国义 张佳 贾森浩 胡忠洲 Xu Yongle, Jia Xin, Guo Wei, Liu Xiaoping, Du Xin, Sun Guoyi, Zhang Jia, Jia Senhao, Hu Zhongzhou( Department of Vascular Surgery, People's Liberation Army General Hospital, Beijing 100853, China)
出处 《中华外科杂志》 CAS CSCD 北大核心 2016年第8期617-619,共3页 Chinese Journal of Surgery
关键词 外周血管疾病 动脉 药物涂层球囊 Peripheral arterial disease Arteries Drug coated balloon
作者简介 通信作者:郭伟,Email:pla301dml@vip.sina.com
  • 相关文献

参考文献13

  • 1Thukkani AK, Kinlay S. Endovascular intervention for peripheral artery disease[ J]. Circ Res,2015,116 (9) : 1599-1613. 被引量:1
  • 2Scheller B, Hehrlein C, Bocksch W, et al. Treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter[ J ]. N Engl J Med,2006,355(20) :2113-2124. 被引量:1
  • 3Baerlocher MO, Kennedy SA, Rajebi MR, et al. Meta-analysis of drug-eluting balloon angioplasty and drug-eluting stent placement for infrainguinal peripheral arterial disease [ J ]. J Vasc Interv Radio1,2015,26(4) :459-473. 被引量:1
  • 4Scheller B, Speck U, Abramjuk C, et al. Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis [J]. Circulation,2004,110(7) :810-814. 被引量:1
  • 5Tepe G, Zeller T, Albrecht T, et al. Local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg[J]. N Engl J Med, 2008,358(7) :689-699. 被引量:1
  • 6Ng VG, Mena C, Pietras C, et al. Local delivery of paclitaxel in the treatment of peripheral arterial disease[J]. EurJ Clin Invest, 2015,45 ( 3 ) :333-345. 被引量:1
  • 7Scheinert D, Sehulte KL, Zeller T, et al. Paelitaxel-releasing balloon in femorepopliteal lesions using a BTHC exeipient : twelve- month results from the BIOLUX P-I randomized trial [ J ]. J Endovasc Ther,2015,22( 1 ) :14-21. 被引量:1
  • 8Fanelli F, Cannavale A, Corona M, et al. The "DCBELLUM"-- lower limb multilevel treatment with drug eluting balloon-- randomized trial : 1-year results [ J ]. J Cardiovasc Surg ( Torino), 2014,55(2) :207-216. 被引量:1
  • 9Schillinger M, Sabeti S, Loewe C, et al. Balloon angioplasty versus implantation of nitinol stents in the superficial femoral artery [ J ]. N Engl J Med ,2006,354 ( 18 ) : 1879-1888. 被引量:1
  • 10Tepe G, Laird J, Sehneider P, et al. Drug-coated balloon versus standard percutaneous transluminal angioplasty for the treatment of superficial femoral and popliteal peripheral artery disease: 12- month results from the IN. PACT SFA randomized trial [ J ]. Circulation ,2015,131 ( 5 ) :495-502. 被引量:1

同被引文献35

引证文献5

二级引证文献11

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈