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无偿献血者不规则抗体筛查与输血安全 被引量:1

Irregular antibody screening among blood donars and the safety of blood transfusion
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摘要 目的分析无偿献血人群中不规则抗体的类型及人群分布规律,探讨其与临床安全输血的关系。减少输血反应,提高血液输注疗效,旨在为临床提供健康、安全、有效的血液制品。方法对2012年至2014年安阳市无偿献血者190 310份血液标本进行不规则抗体的初筛及确认,对不规则抗体的类型、频次进行回顾性统计分析。结果我市无偿献血人群血型不规则抗体阳性率为0.059%(113/190 310),发现MN系统抗体46例,占40.71%;冷抗体33例,占29.20%;Lewis系统抗体11例,占9.73%;Lutheran系统抗体1例,占0.88%;Rh系统抗体9例,占7.96%;补体致敏抗体2例,占1.77%;ABO亚型抗体6例,占5.31%;不明抗体5例,占4.42%。不规则抗体阳性率男、女性别比较,χ~2=16.75,P〈0.05;不同年龄阶段比较,χ~2=2.21,P〉0.05;A、B、O、AB四种血型比较,χ~2=12.83,P〈0.05。结论本市无偿献血人群中不规则抗体阳性率较低,应采用更为敏感的方法进行筛查。不规则抗体筛查能够降低和避免输血反应,提高输注效果,有利于保障临床输血安全。 Objective To analyze the types of irregular antibodies and their distribution law among blood donors as well as investigate their association with the safety of clinical transfusion in order to reduce transfusion reactions and make blood transfusion more effective in theraphy,so as to provide normal,safe and effective blood products for clinical medicine. Methods Employ screening test and confirmation test upon 190 310 copies of blood samples from blood donors of Anyang city,and retrospectively analyze the types and frequency of irregular antibodies. Results The positive rate of irregular antibodies among blood donors from our city was 0. 059 %( 113 /190 310),46 cases were positive for MN system antibody,accounting for 40. 71 %; 33 cases cold antibody,accounting for 29. 20 %; 11 cases Lewis system antibody,accounting for 9. 73 %; 1 case Lutheran system antibody,accounting for 0. 88 %; 9 cases Rh system antibody,accounting for 7. 96 %; 2 cases compliment activating antibody,accounting for 1. 77 %; 6 cases ABO subtype,accounting for 5. 31 %; 5 cases unindentified antibodies,accounting for 4. 42 %; compared the positive rate in male and female,χ2= 16. 75,P〈0. 05; in terms of age group,χ2=2. 21,P〈0. 05; compared A,B,O and AB blood type,χ2= 12. 83,P〈0. 05. Conclusion The positive rate of irregular antibody among blood donors from our city is comparatively low,so more sensitive methods should be employed for screening test. Irregular antibody screening can decrease or avoid transfusion reactions,improve transfusion effects,and ensure the safety of clinical blood transfusion.
作者 冯娟 Feng Juan. Anyang Blood Center, Anyang 455000, China
出处 《临床医学》 CAS 2016年第10期33-35,共3页 Clinical Medicine
关键词 无偿献血者 不规则抗体 筛查 输血安全 Blood donor Irregular antibody Screening test Safety of blood transfusion
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