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淮安市居民2010年新发恶性肿瘤患者生存率分析 被引量:6

Analysis of survival rates among residents newly diagnosed with malignant cancers during 2010 in Huai'an City
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摘要 目的淮安地处淮河流域里下河下游地区,系全国恶性肿瘤高发区之一,肿瘤的高发生与死亡所致的疾病负担已成为当地一个严峻的公共卫生问题。研究淮安市居民2010年新发肿瘤患者的生存状况,为肿瘤的综合防治提供科学依据。方法收集淮安市恶性肿瘤随访登记系统2010—01~01—12—31新发10383例患者资料,并进行跟踪随访,随访截止日期为2015—12—31,采用Life—table过程计算观察生存率(observed survival rate,OS)与相对生存率(relative survival rate,RS),不同性别、年龄组间肿瘤生存率比较采用Log-rank过程分析。结果全部肿瘤患者5年OS与RS分别为21.73%和25.12%。发病前5位恶性肿瘤为食管癌、肺癌、胃癌、肝癌和结直肠肛门癌,食管癌5年RS为26.95%,肺癌为12.01%,胃癌为27.73%,肝癌为8.41%,结直肠肛门癌为35.07%。男性肿瘤患者5年OS明显低于女性,x2=100.933,P〈0.001;但发病前5位的恶性肿瘤患者5年OS,男性与女性差异均无统计学意义,P〉0.05。全部肿瘤病例、食管癌、肺癌、胃癌与结直肠肛门癌各年龄组的5年OS,均随着年龄的增加而呈下降趋势,P趋势〈0.001。结论在淮安市主要恶性肿瘤中,肝癌、肺癌、食管癌和胃癌的生存状况较差,结直肠肛门癌和女性乳腺癌生存状况相对较好,女性恶性肿瘤患者总体生存期高于男性。 OBJECTIVE Huai'an is located in the lower reaches of Lixiahe area of the Huaihe River basin, which is one of the high incidence of malignant tumors, The high incidence and mortaility caused disease burden, which had become a seriouse problem of public health. The objective of this study was to analyze survival rates of residents newly diagnosed with malignant cancers during 2010 in Huai'an and to provide the base strategies for cancer comprehensive prevention and control. METHODS Totally 10 383 newly diagnosed with malignant cancers from cancer registration system were collected during January lst,2010 and December 31st, 2010, and followed up until December 31st, 2015. Using the Life-table program to analyze observed survival rate (OS) and relative survival rate (RS). Log-rank test was used to compare survival differences among different gender and age groups. RESULTS The 5-year OS and 5-year RS of all patients were 21.73% and 25.12% respectively. The 5-year relative survival rates of the top five tumors, including esophagus cancer, lung cancer, gastric cancer, liver cancer, colorectal anal cancer, were 26.95 %, 12.01%, 27.73% , 8. 41% and 35.07 % , respectively. The analysis between different gender were found that the 5-year observed survival rate of all male patients was significantly lower than that of females (X2 = 100. 933, P〈0. 001). However, the survival of the top five tumor had no significant difference between different gender (P〈0. 05). The 5-year observed survival rates of all and the esophagus cancer, lung cancer, gastric cancer and colorectal anal cancer patients were decreased significantly with the increasing age (P trend〈0. 001). CONCLUSIONS It is shown from the results above that the survival rates of liver cancer, lung cancer, esophagus cancer and gastric cancer were significantly lower, while the prognosis of colorectal anal cancer and female breast cancer were relatively better. The overall survival of female was significantly higher than that of male in Huai�
作者 骆善彩 潘恩春 何源 张芹 王闯 周金意 LUO Shan-cai1 , PAN En-chun1 , HE Yuan1 , ZHANG Qin1 , WANG Chuang1 , ZHOU Jin-yi2(1. Huai'an Center for Disease Control and Prevention, Huai'an 223001 , P. R. China; 2. Deopartment of Chronic Disease , Jiangsu Provincial Center for Disease Control and Prevention , Nanjing 210009,P. R. China)
出处 《中华肿瘤防治杂志》 CAS 北大核心 2016年第16期1049-1052,共4页 Chinese Journal of Cancer Prevention and Treatment
基金 江苏省卫生厅预防医学基金(Y2013034) 淮安市应用研究与科技攻关(社会发展)项目(HAS2014013-4)
关键词 恶性肿瘤 观察生存率 OS 相对生存率 RS 淮安 cancer observed survial rates OS relative survial rates RS Huai'an
作者简介 骆善彩,男,江苏沭阳人,硕士,公卫医师,主要从事公共卫生与疾病防治的研究工作。Tel:86-517-83671773.E-mail:913631369@qq.com. 【通讯作者简介】潘恩春,男,江苏灌南人,硕士,主任医师,主要从事慢性病预防控制的研究工作。Tel:86-517-83672292,E-mail:hypec@163.com
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