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尿液对羟基苯丙氨酸水平在癌症筛选中的应用研究 预览 被引量:1

Application of urine p-hydroxyphenyl alanine in screening cancer
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摘要 目的探讨尿液中对羟基苯丙氨酸(酪氨酸)尿液检测(TUT)在癌症筛选中的应用。方法取癌症组、非癌症组、健康受试组晨尿,用对水平TUT试剂盒检测,统计分析各组及同组各种疾病间检测结果的差异性。结果癌症组、非癌症组、健康受试组阳性检出率分别为81.3%、30.8%、33.8%,癌症组显著高于非癌症组和健康受试组,差异有统计学意义(P〈0.05);非癌症组和健康受试组阳性检出率差异无统计学意义(P=0.653)。癌症组中胃、食管癌、肠癌阳性检出率显著高于其他类型癌症,差异有统计学意义(P〈0.05);其他类型癌症检出率差异无统计学意义(P=0.449)。非癌症组中糖尿病患者阳性检出率高于其他各种疾病,差异有统计学意义(P〈0.05);其他各种疾病患者阳性检出率差异无统计学意义(P=0.327)。结论尿液TUT能很好地用于癌症患者的筛选,尤其是胃肠道癌症患者。 Objective To evaluate the effect of urine p-hydroxyphenyl alanine test(TUT)in screening cancer.Methods Study subjects were consisted of three groups including cancer patients,non-cancer patients and healthy individuals.Morning urine from the subjects were collected and detected for urine p-hydroxyphenyl alanine(tyrosine)with TUT kit.Chi-square test was used for analysis of differences between the three groups.Results The positive rates of p-hydroxyphenyl alanine in cancer patients(81.3%)was significantly higher than that of non-cancer patients(30.8%)and healthy individuals(33.8%,P〈0.05).The difference of the positive rate between the non-cancer patients and healthy individuals didn′t have statistical significance(P=0.653).In cancer patients,positive rates of gastric,esophageal and colon cancer positive rate were significantly higher than other types of cancer(P〈0.05).And the positive rate of diabetes in non-cancer group was significantly higher than that of other diseases(P〈0.05).Conclusion TUT could be used in screening cancer effectively,especially in screening the gastrointestinal cancer.
作者 徐卫益 许青 陈保德 XU Weiyi;XU Qing;CHEN Baode (Department of Clinical Laboratory ,First Affiliated Hospital of College of Medicine ,Zhejiang University/ Key Laboratory of Clinical in Vitro Diagnoistic Technology of Zhejiang Province, Hangzhou,Zhejiang 310003 ,China)
出处 《国际检验医学杂志》 CAS 2016年第21期2967-2969,共3页 International Journal of Laboratory Medicine
基金 浙江省卫生和计划生育委员会基金项目(2014KYB097) 浙江大学横向科技项目(15-491010-026)
关键词 对羟基苯丙氨酸 筛选 cancer p-hydroxyphenyl alanine screening
作者简介 徐卫益,男,主管技师,主要从事临床基础检验方面的研究。
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