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苍白球与壳核T1WI信号强度比值在新生儿急性胆红素脑病分级及预后中的价值 被引量:7

The value of T1WI signal intensity ratio of globus pallidus to putamen in grading and predicting prognosis of neonatal acute bilirubin encephalopathy
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摘要 目的 探讨新生儿急性胆红素脑病(ABE)苍白球与壳核T1WI信号强度比值(G/P比值)与ABE分级及预后的关系.方法 2013年1月至2015年12月收集85例足月新生儿ABE患儿,依据胆红素致神经功能障碍(BIND)进行评分,分为轻、中、重度组各56、19、10例,分别进行头颅MRI检查;64例患儿半年后随访复查,根据Gesell发育量表评估分为预后良好组44例、预后不良组20例,其中23例复查头颅MRI.测量首次MRI检查的双侧苍白球与壳核T1WI信号强度并计算其G/P比值,记录检查时日龄.轻、中、重度3组ABE患儿的G/P比值结果以及日龄的比较采用单因素方差分析,预后良好组、预后不良组采用独立样本t检验进行比较分析.通过ROC曲线分析G/P比值预测预后状况.结果 轻、中、重度组ABE患儿G/P比值分别为1.12±0.05、1.30±0.09、1.38±0.05,差异有统计学意义(F=38.90,P〈0.01),3组间日龄差异没有统计学意义;预后不良组与预后良好组G/P比值分别为1.35±0.08、1.23±0.05,差异有统计学意义(t=-7.48,P〈0.01),日龄差异无统计学意义.预后不良组G/P比值的ROC曲线下面积为0.896,最佳临界点为1.29,敏感度为85.0%,特异度为90.9%.结论 G/P比值可帮助临床对新生儿ABE进行分级;G/P比值可以帮助判断预后,当G/P比值〉1.29时提示患儿预后不良. Objective To discuss the T1WI signal intensity ratio of globus pallidus to putamen in neonatal acute bilirubin encephalopathy(ABE), and its relations with grading and prognosis evaluation in ABE. Methods Eighty-five cases of neonatal acute bilirubin encephalopathy from January 2013 to December 2015 were divided into three groups, including 56 cases of mild group, 19 cases of medium group, 10 cases of severe group depending on the scores of bilirubin induced neurological dysfunction (BIND) and correlated with cranial MRI examination. Sixty-four cases with follow-up for half a year, were divided into good prognosis group (44 cases) and poor prognosis group (20 cases) by Gesell development scales, and 23 patients had cranial MRI examination. Measurements of T1WI signal intensity of globus pallidus and putamen were made, the G/P ratio was calculated, and the day age of children was recorded . The G/P ratio and the day age of light, medium, severe groups using single factor analysis of variance between each other. Good prognosis group, poor prognosis group using homogeneity test of variances and then using independent sample to test for comparative analysis. Analysis of the line of ROC curve of G/P ratio was performed to predict prognosis. Results The G/P ratio of light, medium, severe groups are 1.12±0.05, 1.30±0.09, 1.38± 0.05, the difference had statistical significance(F=38.90,P〈0.01).There was no statistical difference in the three groups of day age. The G/P ratio of good prognosis group and poor prognosis group were 1.35 ± 0.08, 1.23 ± 0.05 respectively,the difference had statistical significance(t=-7.48,P〈0.01), The day age of these groups had no statistical difference. Analysis the ROC curve of G/P ratio, area under curve was 0.896, the best threshold was 1.29 and the sensitivity was 85.0%and the specific degreeswas 90.9%. Conclusion The G/P ratio could help clinical evaluation of neonatal ABE for grading. G/P ratio could predict prognosis, a G/P ratio of greater than 1.29 indi
作者 易明岗 姜忠强 赵建设 巩涛 崔若棣 董春华 宋玉霞 宋丹 王光彬 Yi Minggang, Jiang Zhongqiang,Zhao Jianshe, Gong Tao , Cui Ruodi, Dong Chunhua, Song Yuxia, Song Dan, Wang Guangbin. (Department of Radiology, Jinan Children's Hospital, Jinan 250022, China)
出处 《中华放射学杂志》 CAS CSCD 北大核心 2017年第3期214-218,共5页 Chinese Journal of Radiology
基金 国家自然科学基金(81171380) 国家“十二五”科技支撑计划(2011BAI08B09)
关键词 核黄疸 磁共振成像 苍白球 婴儿 新生 Kernicterus Magnetic resonance imaging Globus pallidus Infant newborn
作者简介 通信作者:王光彬,250021,Email:cjr.wangguangbin@vip.163.com
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  • 1毛健,富建华,陈丽英,王晓明,薛辛东.重度高胆红素血症新生儿苍白球磁共振成像特征及其临床意义[J].中华儿科杂志,2007,45(1):24-29. 被引量:60
  • 2邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第4版.北京:人民卫生出版社,2011:872. 被引量:414
  • 3胡亚美 江载芳.诸福棠实用儿科学[M]第7版[M].北京:人民卫生出版社,2002.1514. 被引量:1282
  • 4Oakden WK, Moore AM, Blaser S, et 81. 1H MR spectroscopic characteristics of kernicterus: a possible metabolic signature. AJNR Am J Neuroradiol,2005,26: 1571-1574. 被引量:1
  • 5Johnston MV, Hoon AH Jr. Possible mechanisms I infants for selective basal ganglia damage from asphyxia, kemicterus, or mitochondrial encephalopathies. J Child Neural, 2000,15:588- 591. 被引量:1
  • 6Barkovich AJ, Westmark KD, Bedi HS, et al. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report. AJNR Am J Neumradiol, 2001,22 : 1786-1794. 被引量:1
  • 7Hoon AH, Belsito KM, Nagae-Poetscher LM. Neuroimaging in spasticity and movement disorders. J Child Neurol, 2003, 18 ( Suppl 1 ) : S25-39. 被引量:1
  • 8Rodl-igues CMP, Sola S, Castro RE, et 81. Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis. J Lipid Res, 2002,43:885-894. 被引量:1
  • 9Martich-Kriss V, Koliass SS, Ball WS. MR findings in kemictems. AJNR Am J Neuroradiol, 1995,16:819-821. 被引量:1
  • 10Amin SB, Ahlfors C, Orlando MS, et al. Bilirubin and aerial auditory brainstem response in premature infants. Pediatrics, 2001,107:664-670. 被引量:1

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