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帕金森病患者脑内葡萄糖代谢特点的18F—FDG PET研究 被引量:6

Characteristics of cerebral glucose metabolism on 18F-FDG PET imaging in patients with Parkinson's disease
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摘要 目的验证PD患者脑葡萄糖代谢特点在不同显像条件下的可重复性,为开展多中心研究奠定基础。 方法回顾性分析复旦大学附属华山医院33例PD患者(男15例、女18例,年龄38~79岁)和33名健康对照者(男15名、女18名,年龄40~77岁),以及中山大学附属第一医院17例PD患者(男10例、女7例,年龄44~74岁)和17名健康对照者(男6名、女11名,年龄42~67岁)静息状态下18F-FDG PET显像的数据。应用SPM软件分别对2家医院PD患者和健康对照者的PET图像行两样本t检验,用族错误率(FWE)校正P〈0.05为检验水平,获得差异具有统计学意义的像素点,最终获得2组PD患者葡萄糖代谢异常的脑区,并比较其变化特点的异同。 结果复旦大学附属华山医院PD患者与对照组相比,表现为小脑及脑桥、双侧苍白球和壳核、双侧丘脑、双侧感觉运动皮质葡萄糖代谢增高,累及范围8 110个像素;双侧枕叶、顶叶葡萄糖代谢减低,累及范围2 810个像素(P〈0.05);中山大学附属第一医院PD患者与对照组相比,表现为小脑及脑桥、双侧苍白球和壳核、双侧丘脑葡萄糖代谢增高,累及范围15 573个像素;双侧枕叶、顶叶和双侧额叶葡萄糖代谢减低,累及范围3 945个像素(P〈0.05)。 结论2家医院的PD患者在不同的显像条件下均存在小脑及脑桥、双侧苍白球、丘脑葡萄糖代谢增高,双侧枕叶、顶叶葡萄糖代谢减低的表现,良好的可重复性为18F-FDG PET显像用于PD鉴别诊断的多中心研究奠定了基础。 Objective To validate the reproducibility of abnormal cerebral metabolic characteristics in PD patients from different medical centers using lSF-FDG PET imaging. Methods A total of 108 sub- jects who were referred for resting-state brain ISF-FDG PET imaging were retrospectively reviewed. Thirty- three PD patients ( 15 males, 18 females, age: 38-79 years) and 33 age-matched healthy controls ( 15 males, 18 females, age: 40-77 years) underwent evaluation at Shanghai Huashan Hospital Affiliated to Fu- dan University. Seventeen PD patients (10 males, 7 females, age: 44-74 years) and 17 age-matched healthy controls (6 males, 11 females, age: 42-67 years) underwent evaluation at the First Affiliated Hos- pital of Sun Yat-sen University. SPM was used to investigate the cerebral metabolic characteristics of the pa- tients with two-sample t test. Statistically significant voxels were obtained by using familywise error rate (FWE; P〈0.05). Two sets of PD patients with abnormal glucose metabolism of brain regions were obtained and the cerebral metabolic characteristics were compared. Results Regarding the PD patients from Shang- hai Huashan Hospital, the features of cerebral glucose metabolism by SPM analysis were demonstrated as follows : increased metabolism was found in the region of pons, cerebellum, thalamus, putamen and palli- dum, while decreased metabolism was displayed in the region of parietal lobe and occipital lobe. The in-creased regions referred to 8 110 voxels and decreased regions referred to 2 810 voxels (P〈O.05). The simi- lar metabolic pattern was found in PD patients from the First Affiliated Hospital of Sun Yat-sen University. The increased metabolism was shown in the regions of pons, cerebellum, thalamus, putamen and pallidum, and referred to 15 573 voxels. The metabolism-decreased regions included parietal lobe, occipital lobe and frontal lobe, and referred to 3 945 voxels (P〈0.05). Conclusions 18SF-FDG PET/CT imaging results dem- onstrate similar metabolic pa
作者 蒋承峰 葛璟洁 史新冲 邬剑军 王坚 吴平 张祥松 左传涛 管一晖 Jiang Chengfeng, Ge Jingfie, Shi Xinchong, Wu Jianjun, Wang Jian, Wu Ping, Zhang Xiang- song, Zuo Chuantao , Guan Yihui (PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China ; Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200235, China ( Wu J J, Wang J) ; Department of Nuclear Medicine, the First Affiliated Hospital, Sun Yat-sen Uni- versity, Guangzhou 510080, China ( Shi XC, Zhang XS))
出处 《中华核医学与分子影像杂志》 北大核心 2017年第4期193-197,共5页 Chinese Journal of Nuclear Medicine
基金 国家自然科学基金(81171189,81361120393,81401135)
关键词 帕金森病 代谢 正电子发射断层显像术 脱氧葡萄糖 Parkinson disease Brain Metabolism Positron-emission tomography Deoxyglucose
作者简介 张祥松,Email:sd—zh@163.net 通信作者:左传涛,Email:zuoct—cn2000@126.com
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