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老年高血压患者认知功能与血浆Hcy水平及颈动脉内膜-中层厚度的相关性研究 预览 被引量:1

Study on Relationship among H-type Hypertension, Carotid Artery Intima Media Thickness and Cognitive Impairment in Elderly People
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摘要 探讨老年高血压患者认知功能与血浆同型半胱氨酸(Hcy)水平及颈动脉内膜-中层厚度(IMT)的相关性。选取2014年9月-2016年11月于笔者所在医院就诊的高血压患者233例。进行MMSE量表评估后分为轻度认知障碍组(MCI组)及对照组。采集一般资料、检测Hcy水平及测量IMT值。结果显示,MCI组的年龄、BMI明显高于对照组,心率明显低于对照组,差异有统计学意义。MCI组较对照组Hcy值及IMT值明显增高(P〈0.05)。Hcy及IMT均与MMSE得分呈负相关,Hcy与IMT呈正相关。二元Logistic回归显示,年龄、Hcy、IMT是老年高血压患者轻度认知功能障碍发生的危险因素。提示老年高血压患者轻度认知功能障碍发生与血浆Hcy水平及颈动脉IMT值相关。 To investigate the relationship among H-type hypertension, carotid artery intima media thickness,and cognitive impairment in elderly people. We included 135 patients with MCI and 98 controls with no history of vascular disease. All participants underwent laboratory analyses, a carotid ultrasound, and Mini-Mental State Examination (MMSE). We used the Student's t test, Mantel-Haenszelb test, Sighed rank test and Logistic Regression to examine any associations between IMT, Hcy and cognitive state. We found a significant association between Hcy levels and the risk of MCI (r=- 0.62). We also found a clear association between IMT and the risk of MCI (r=- 0.47). Additionally, we found a correlation between Hcy and IMT (r=0.35). The Logistic Regression revealed a significant association between age and the risk of MCI. The OR for the upper quartile vs the lower quartile was1. 27, (95%CI 1. 15- 1. 41, P〈0. 01). The Logistic Regression showed a clear association between Hcy levels and the risk of MCI, OR for the upper vs the lower quartile was 1.63,(95%CI 1.40-1.91,P〈0.01), The Logistic Regression also showed a clear association between IMT and risk of MCI, OR for the upper vs the lower quartile was 5.14, (95%CI 1.06-24.95,P〈0. 05). Age, Hey levels and IMT increase the independent risk factors with cognitive impairment. Cognitive impairment in elderly patients with hypertension was associated with plasma homocysteine levels and carotid artery intima media thickness.
作者 巩祺芸 王晓丽 GONG Qi-yun, WANG Xiao-li. (The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China)
出处 《医学与哲学:B》 2017年第3期29-31,共3页 Medicine and Philosophy
关键词 原发性高血压 轻度认知功能障碍 同型半胱氨酸 颈动脉内膜-中层厚度 primary hypertension, homocysteine, intima-media thickness, cognitive impairment
作者简介 巩祺芸(1990-),女,硕士研究生,研究方向:老年心血管方向。 通讯作者:王晓丽(1963-),女,主任医师,硕士生导师,研究方向:老年心血管方向。E-mail:wxl212219@sina.com
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