Objective： To observe the efficacy and safety of human umbilical cord mesenchymal stem cells transplantation in the treatment of chronic insomnia. Methods： 39 cases of patients with chronic insomnia were randomly divided into transplantation group（n=19） and control group（n=20）. The MOS item short from health survey（SF-36） and Pittsburgh sleep quality index（PSQI） were used to evaluate the clinical efficacy. Two groups of patients were followed up to 12 months. Results： （1）For the cell transplantation patients, life quality score and sleep quality score were significantly better than before treatment after 1 month, and continued better than before in the follow-up period; For the comparison group patients treated with alprazolam, sleep quality score was significantly better than before treatment after 2 weeks, but the life quality score and sleep quality score decreased to the same level of before treatment after 3 months, and continued until the end of follow- up; （2）At 2 weeks after treatment, sleep quality score in comparison group was significantly higher than transplantation group; 1 month after treatment, sleep quality score and life quality score had no significant differences between two groups; 2 months after treatment, sleep quality score in transplantation group was significantly higher than the comparison group, which continued until the end of the follow-up. 3 months after treatment, ire quality score in transplantation group was significantly higher than the comparison group, which lasted until the end of follow-up; （3）For the control group, 80% patients returned to insomnia after stopping alprazolam; But for the cell transplantation group, sleep quantity and life quality improvement without obvious adverse reactions continued for 12 months after one time treatment. Conclusion： Intravenous infusion of human umbilical cord mesenchymal stem cells is effective for the chronic insomnia, which starts at 1 month after transplantation and sustains at least for 1 year.
Chinese Journal of Clinical Psychology
Umbilical cord mesenchymal stem ceils