Objective To observe the therapeutic effect of levodopa combined with pramipexole in the treatment patients with Parkinson＇s disease and to understand its influence on the mobility of patients. Methods 72 patients with Parkinson＇s disease in Affiliated Hospital of Hangzhou University from June 2013 to January 2015 were enrolled and randomly divided into two groups with 36 cases of each. Patients in study group were treated with both levodopa and pramipexole, while patients in control group were only given levodopa. The therapeutic effects were compared after 18 weeks of oral treatment. Results The scores of HAMA and HAMD of patients in study group were lower than that of controls, the difference was statistically significant （t=4.422, 4. 032, P〈0. 05）. Meanwhile, the UPDRS Ⅲ scores of patients in study group in treatment time points of 6, 12 and 18 weeks were all significantly lower than that of controls （t=3. 454, 4. 267, 4. 806, P〈0.05）. After treatment, patients in study group received higher scores in physical, psychological, independent, social and environmental aspects of WHOQOL2BREF compared with patients in control group （t = 3. 342, 3. 526, 3. 503, 3. 114, 3. 051, P%0.05）. The overall effective rate of patients treated with both levodopa and pramipexole was much higher than that of those treated with only levodopa （91.67% vs. 72.22%, x^2 =6. 635, P〈0.05）. Conclusions Levodopa combined with pramipexole in the treatment of patients with Par- kinsonPs disease can effectively improve their mobility, relieve their negative emotions and improve the quality of life while does not cause more adverse reactions.
China Preventive Medicine