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双歧杆菌三联活菌散联合三联疗法治疗儿童幽门螺杆菌感染的临床疗效观察 被引量:4

Live Combined Bifidobacterium, Lactobacillus and Enterococcus Powder Combined with the Triple Therapy on Helicobacter Pylori Infection in Children
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摘要 目的:探讨双歧杆菌三联活菌散联合抗幽门螺杆菌标准三联疗法对幽门螺杆菌根除率的影响和预防不良反应发生的作用。方法:选取我院2014年11月至2016年11月收治的幽门螺杆菌感染患儿200例,随机分为对照组、观察1组和观察2组。对照组患儿使用抗幽门螺杆菌标准三联疗法,即质子泵抑制剂(奥美拉唑)、阿莫西林、克拉霉素,连用2周;观察1组患儿给予双歧杆菌三联活菌散同时联合三联疗法共用2周;观察2组在观察1组的2周疗法前后各单用双歧杆菌三联活菌散2周。青霉素过敏者阿莫西林替换为甲硝唑。在整个治疗过程中观察并记录不良反应发生情况直至停药4周后复查幽门螺杆菌根除情况。结果:对照组幽门螺杆菌根除率61.43%,不良反应发生率45.71%;观察1组根除率76.92%,不良反应发生率24.62%;观察2组根除率80.00%,不良反应发生率12.31%。三组患儿根除率及不良反应发生率比较差异有统计学意义(P〈0.05),但观察1组与观察2组比较差异无统计学意义(P〉0.05)。结论:标准三联疗法基础上联用双歧杆菌三联活菌散治疗可以提高幽门螺杆菌根除率,并可减少不良反应发生率,提高治疗安全性,增加治疗有效性。延长双歧杆菌三联活菌散疗程至6周与2周疗程的疗效及不良反应比较差异无统计学意义。 Objective: To observe the efficacy, safety and precaution of adverse reactions of live combined Bifidobacterium, Lactobacillus and Enterococcus powder (Bifico) combination with the triple therapy for the eradication of Helicobacter pylori (11. pylori) infection. Methods: Two hundreds children with H. pylori infection were randomly divided into three groups. The control group received the triple therapy including omeprazole, amoxicillin and clarithromycin. The course of treatment was two weeks. The observation group i received Bifico combined with triple therapy. The course of treatment was two weeks, too. The observation group 2 received Bifico during the 6 weeks, and the triple therapy at the 3^rd and 4^th week. For those who were allergic to penicillin, metronidazole could be used. Adverse reactions and eradication rate of tl, pylori were recorded 4 weeks after drug withdrawal. Results: The eradication rate of H. pylorie in the control group was 61.43% while the observation group 1 was 76. 92% and the observation group 2 was 80. 00%. The adverse effects rate of control group was 45, 71% while the observation group 1 was 24.62% and the observation group 2 was 12. 31%. The differences among the three groups were significant (P〈0. 05 ). Conclusion: Bifico combined with triple therapy is effective in the treatment of 1-1. pylori eradication and can reduce the incidence of adverse reactions. The difference is not significant while extending the course to six weeks.
作者 王文妤 蒋丽蓉 邓朝晖 Wang Wenyu, Jiang Lirong, Deng Zhaohui (Shanghai Children' s Medical Center, Shanghai 200127, China)
出处 《儿科药学杂志》 CAS 2017年第7期8-12,共5页 Journal of Pediatric Pharmacy
关键词 幽门螺杆菌 根除率 双歧杆菌三联活菌散 三联疗法 儿童 Helicobacter pylori eradication rate live combined Bifidobacterium, Lactobacillus and Enterococcus powder triple therapy children
作者简介 王文妤(1985.06~),女,大学本科,主治医师,主要从事儿童消化系统疾病研究,E—mail:drskywong@126.com。 通讯作者:邓朝晖(1971.01~),女,博士,副主任医师,主要从事儿童消化系统疾病研究,E-mail:dzhrj@163.com。
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