Objective To investigate the clinical effect of tauroursodeoxycholic acid in treatment of nonalcoholic fatty liver disease.Methods 172 patients with nonalcoholic fatty liver disease were selected in a hospital from Decem- ber 2015 to December 2016 and divided into two groups by random number table method.86 patients treated with ur- sodeoxycholic acid combined with polyene phosphatidylcholine were selected as the control group and 86 patients treat- ed with tauroursodeoxycholic acid combined with polyene phosphatidylcholine as observation group.Liver function and blood lipid detection of the two groups were given before and after the treatment to compare the clinical effect and side effect of the treatment. Results After treatment, the total cholesterol, triglyceride, low density lipoprotein choles- terol, alanine aminotransferase, spartate aminotransferase, glutamyl transpeptidase and BMI decreased in the two groups （P 〈 0.05）.High density lipoprotein cholesterol increased in two groups （P 〈 0.05）.Total cholesterol, riglyceride ,low density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, glutamyl transpeptidase and BMI in observation group were lower than those of the control group（P 〈 0.05）.High density lipoprotein cholesterol, total ef- fective rate in observation group were higher than those of the control group（P 〈 0.05）. Conclusion Tauroursodeoxy- cholic acid has a significant effect in treatment of nonalcoholic fatty liver disease, significantly improving the patient＇s blood lipids and liver function.
Chinese Journal of Convalescent Medicine
Nonalcoholic fatty liver