目的探讨阿托伐他汀钙片强化治疗急性脑梗死的临床效果。方法收集2013年5月-2015年6月在我科住院的急性脑梗死患者92例,随机分成观察组46例和对照组46例。在常规治疗基础上,观察组给予40 mg阿托伐他汀钙片,对照组给予20 mg阿托伐他汀钙片,根据NIHSS量表评分进行疗效评价。结果两组患者治疗后14 d、3个月的C-反应蛋白,总胆固醇（TC）,低密度脂蛋白胆固醇（LDL-C）水平均较治疗前显著下降,而观察组的下降水平明显高于对照组,差异有统计学意义（P〈0.05）,两组患者治疗后的高密度脂蛋白胆固醇（HDL-C）均较治疗前升高,且观察组的升高水平高于对照组,差异有统计学意义（P〈0.05）。观察组治疗后1、3、6、12个月的NIHSS评分均低于对照组,差异有统计学意义（P〈0.05）。观察组的总体治疗有效率（95.65%）高于对照组（78.26%）,差异有统计学意义（P〈0.05）。观察组的不良反应发生率为10.87%,对照组为13.04%,两组差异无统计学意义（P〉0.05）。结论强化阿托伐他汀钙片治疗急性脑梗死的效果确切,能减轻炎症反应和快速降低血脂水平,可以改善预后,值得临床推广应用。
Objective To explore the clinical effect of intensive Atorvastatin Calcium Tablets in treatment of acute cerebral infarction.Methods 92 inpatients with acute cerebral infarction treated in department from May 2013 to June 2015 were collected and they were randomly divided into the observation group and control group,and there were 46 cases in each group.On the basis of routine treatment,the observation group was treated with 40 mg Atorvastatin Calcium Tablets and the control group was treated with 20 mg Atorvastatin Calcium Tablets.Clinical effect was evaluated by the change of NIHSS after treating.Results C-reactive protein,LDL-C and TC level were obviously decreased in two groups after14 days and 3 months treatment compared with before treatment,and the decline level in the observation group was significantly higher than that of the control group,and there was a statistical difference（P 0.05）.HDL-C level were increased in two groups after treatment,and the elevated level in the observation group was higher than that of the control group,and there was a statistical difference（P〈0.05）.NIHSS score of the observation group was lower than that of the control group after 1,3,6,12 months,and there was a statistical difference（P〈0.05）.The total effective rate of the observation group（95.65%） was higher than that of the control group（78.26%）,and there was a statistical difference（P〈0.05）.The incidence of adverse reactions was 10.87% in the observation group and it was 13.04% in the control group,and there was no significant difference between the two groups（P〉0.05）.Conclusion The effect of intensive Atorvastatin Calcium Tablets in treatment of acute cerebral infarction is exact and it can reduce inflammation,rapidly drop the blood lipid level and improve the prognosis.It is worthy of clinical promotion and application.
China Modern Medicine
Atorvastatin Calcium Tablets
Acute cerebral infarction