Objective To explore the clinical efficacy of the radiofrequency ablation combined with transcatheter arterial chemoem- bolization and the transcatheter arterial chemoembolization for the hepatoeellular carcinoma. Methods In this retrospective study,58 cases of the hepatoeellular carcinoma patients in Beihua University from June 1,2009 to December 1,2015 were included into survey. 25 pa- tients with the RFA ＋ TACE were selected as experimental group, and 33 cases with the TACE were selected as control group. We detec- ted and analysis the liver function, NRL,AFP,PIVKA - Ⅱ , CT/MRI before and after one week or month of the therapy. All the patients were followed up for 1 year. Results （1） The two methods did not increase the damage of liver. （2） the NLR of the two gropes was de- creased. The experimental group was more obvious and the difference was statistically significant （ P 〈 O. 05 ）, （3） The decline about PIVKA -Ⅱof the experimental group was more obvious than the control group, and the difference was statistically significant（ P 〈 0.05 ）. （4） The AFP levels of the two groups were decreased, and the difference had statistically significant（ P 〈 O. 05） ; but the comparison among the two groups had no statistically significant（ P 〉 0.05 ）. （5）The remission rate of the two groups was 88.0% ,63.6%, and the difference was statistically significant（P 〈 0.05 ）. （6）But the survival rates of the experimental and control groups respectively were 76.0% （19/ 25）. 72.7% （24/33）, and the difference has no statistically significant （ P 〉 O. 05 ）. Conclusion The combined intervenient therapies can keep a better balance between relieving immune suppression and switching the inflammatory state,and will not obviously accentuated the liver damage. The combined treatment can improve therapeutic efficacy, and is worthy of clinical promotion.
Journal of Medical Research
Transcatheter arterial chemoembolization