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自拟疏肝健脾化浊汤联合多烯磷脂酰胆碱对新发非酒精性脂肪肝患者炎性反应和氧化应激的影响 预览 被引量:5

Effect of Shugan Jianpi Huazhuo decoction combined with polyene phosphatidylcholine on inflammatory reaction and oxidative stress in patients with newly diagnosed nonalcoholic fatty liver disease
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摘要 目的 观察自拟疏肝健脾化浊汤联合多烯磷脂酰胆碱治疗新发非酒精性脂肪肝(NAFLD)患者的疗效及对炎性反应和氧化-抗氧化系统失衡的影响。方法 将120例新发NAFLD患者随机分为观察组60例及对照组60例,对照组给予多烯磷脂酰胆碱治疗,观察组在对照组治疗基础上给予自拟疏肝健脾化浊汤治疗,2组疗程均为8周。观察2组治疗前后中医症候积分、血脂指标、肝功能指标、肝脏B超、肝/脾CT比值及血清炎性指标[白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)]和氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)]变化情况。结果 2组治疗后主症(面色萎黄、脘腹胀满、倦怠乏力、肝区隐痛)、次症(体态丰腴、身目发黄、食欲不振、大便不畅)积分均显著降低(P均〈0.05),且观察组上述积分均明显低于对照组(P均〈0.05);2组治疗后血脂、肝功能指标、肝脏B超、肝/脾CT比值及血清IL-6、IL-8、TNF-α、SOD、MAD、GSH-Px水平均显著改善(P均〈0.05),且观察组上述指标改善情况均明显优于对照组(P均〈0.05)。结论 自拟疏肝健脾化浊汤联合多烯磷脂酰胆碱治疗新发NAFLD患者能够显著改善临床症状,调节血脂紊乱,保护肝功能,机制可能与抑制炎性反应、促进氧化-抗氧化系统平衡有关。 Objective It is to observe the curative effect of Shugan Jianpi Huazhuo decoction(SGJPHZD) combined with polyene phosphatidylcholine in the treatment of newly diagnosed nonalcoholic fatty liver disease(NAFLD) and its influence on the inflammatory reaction and the imbalance of oxidation antioxidant system. Methods 120 patients with newly diagnosed NAFLD were randomly divided into the observation group(60 cases) and the control group(60 cases),the control group was treated with polyene phosphatidylcholine,and the observation group was treated with combination of SGJPHZD and polyene phosphatidylcholine,the course of treatment in the 2 groups was 8 weeks. The changes of TCM syndrome integral,blood lipid,liver function,liver ultrasound,liver/spleen CT ratio and serum inflammatory markers [interleukin-6(IL-6),IL-8,tumor necrosis factor α(TNF-α) ]and oxidative stress index [superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px) ] were observed before and after treatment in the two groups. Results After treatment,the scores of main symptoms(pain pale complexion,abdominal distention,lassitude,liver),secondary symptoms(plump,yellowing of the body and eyes,loss of appetite,poor stool) were significantly decreased(all P < 0. 05),and the scores in the observation group were significantly lower than those in the control group(all P < 0. 05); the values of blood lipid,liver function index,liver B ultrasound,liver/spleen CT ratio and the levels of serum IL-6,IL-8,TNF-alpha,SOD,MAD,GSH-Px were significantly improved(all P < 0. 05) in the two groups,and the improvement of the above indexes in the observation group was significantly better than that in the control group(P < 0. 05). Conclusion SGJPHZD Combined with polyene phosphatidylcholine in the treatment of newly diagnosed NAFLD patients can significantly improve the clinical symptoms,regulating blood lipid disorder,protect liver function,the mechanism may be related to inhibiting inflammatory reaction and promoting the balance of oxidation-antioxidatio
作者 王叶 王爱兵 赵相 张永刚 WANG Ye;WANG Aibing;ZHAO Xiang;ZHANG Yonggang;Qinghai Provincial People's Hospital;
机构地区 青海省人民医院
出处 《现代中西医结合杂志》 CAS 2017年第33期3680-3684,3762共6页 Modern Journal of Integrated Chinese Traditional and Western Medicine
关键词 疏肝健脾化浊汤 多烯磷脂酰胆碱 非酒精性脂肪肝 炎性反应 氧化-抗氧化系统 Shugan Jianpi Huazhuo decoction polyene phosphatidylcholine nonalcoholic fatty liver inflammatory reaction oxidation-antioxidation system
作者简介 王叶,女,副主任医师,主要从事临床内分泌科疾病的诊治与研究.
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