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D3胚胎短暂延长培养对IVF/ICSI-ET妊娠结局的影响 预览

Effect of Extended Culture in Short Duration for D3 Embryos on the Pregnancy Outcome of IVF/ICSI-ET
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摘要 目的:探讨短暂延长培养辅助生殖助孕中第3天(D3)上午的胚胎7~8小时在体外受精/卵胞浆内单精子注射一胚胎移植(IVF/ICSI-ET)中的应用价值。方法:本中心458个取卵周期根据培养方法分为短暂延长培养组(A组)及常规培养组(B组),对其临床妊娠结局进行回顾全面分析及比较。结果:通过延长培养,有52.72%的胚胎发生卵裂球数目增加或致密化。A组新鲜周期和冻融胚胎移植(FET)周期的胚胎种植率显著高于B组(P〈0.05),A组平均胚胎种植率也显著高于B组(P〈0.05)。A组新鲜周期和FET周期的临床妊娠率、活产率均高于B组,但差异均无统计学意义(P〉0.05),而A组平均临床妊娠率、平均活产率以及每移植周期活产率均显著高于B组(P〈0.05)。A组新鲜周期和FET周期的流产率低于B组,但差异无统计学意义(P〉0.05);A组平均流产率显著低于B组(P〈0.05),A组每移植周期的新生儿出生率显著高于B组(P〈0.001),并且A组每移植胚胎的新生儿出生率也显著高于B组(P〈0.001)。A、B两组患者的累积妊娠率、累积活产率以及平均新生儿体质量间差异均无统计学意义(P〉0.05)。结论:对IVF/ICSI—ET助孕患者D3上午的胚胎延长培养7~8小时,并没有提高累积妊娠率和活产率,但是可以帮助选择更具有发育潜能的胚胎优先用于移植,提高了胚胎着床率和临床妊娠率,从而改善了患者每个移植周期的妊娠结局。 Objective:To investigate the application value of extended culture in short duration for 7 -8 hours of embryos in day 3 morning in in-vitro fertilization-embryo transfer(IVF-ET). Methods: A total of 458 cycles of oocyte retrievale were collected retrospectively in our center of clinical reproduction medicine and they were assigned to extended culture group(A)and normal culture group(B). The clinical pregnancy outcome of the two groupswere analyzed. Results: Through extended culture, the rate of embryos with the increased number of cleavage or compaction was 52.72%. In fresh transfer cycles and FET cycles,the implantation rate in group A was significantly higher than that in group B ( P 〈 0.05). Compared with group B, the average clinical pregnancy rates,the average live birth rates and the average live birth rates per ET of group A were significantly higher( P 〈 0.05). The average abortion rate of group A was significantly lower than group B( P 〈 0.05). The rate of newborn infant per ET and newborn infant per transferred embryo in group A were significantly higher than that in group B (P 〈 0. 001 ), In addition,there were no significant differences in the cumulative clinical pregnancy rates, cumula- tive live birth rates and the weight of average newborn infant between two groups( P 〉0.05). Conclusions:The extended culture of short duration in day 3 morning in IVF-ET patients can notincrease the cumulative pregnancy rates and live birth rates. However,it may help us to select the superiorembryos as a matter of priority to be trans- ferred and then the pregnancy outcomes of patients were improved in per embryo transfer cycle.
作者 赵晓鹏 王玲 张文华 张丽媛 贾俊龙 桑元坤 常飞 ZHAO Xiaopeng,WANG Ling,ZHANG Wenhua, et al (Center of Clinical Reproductoin Medicine, Lanzhou General Hospital of Lanzhou Military Area Command, PLA, Lanzhou Gansu 730050,China)
出处 《实用妇产科杂志》 CSCD 北大核心 2018年第1期55-60,共6页 Journal of Practical Obstetrics and Gynecology
基金 兰州军区医药卫生科研项目(编号:CLZ14JB08)
关键词 短暂延长培养 体外受精/卵胞浆内单精子注射-胚胎移植 妊娠结局 Extended culture in short duration In vitro fertilization/Intra-cytoplasmic sperm injection-embryo transfer Pregnancy outcome
作者简介 通讯作者:王玲,E-mail:Ling-1224@sohu.com
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