Objective To investigate the application value of double contrast ultrasonography in the evaluation of neoadjuvant chemotherapy for gastric cancer with liver metastasis.Methods A total of 82 patients with gastric cancer with liver metastasis and neoadjuvant chemotherapy were selected,who were divided into effective group（ n = 62） and progression group（ n = 20） according to the disease condition.The ultrasound double contrast parameters were compared between the two groups before and after chemotherapy. The microvessel density（ MVD） was measured by immunohistochemical staining after operation.Then analyze the correlation between ultrasound double contrast parameters and MVD.Results The peak intensity（ PI） of the 3 cycles after treatment was significantly lower than that before treatment,the initial enhancement time（ RT） and the peak arrival time（ TTP） were significantly higher than those before treatment（ P〈0.05）. After 3 cycles,the PI in the effective group was significantly lower than that in the progressive group,and the RT and TTP levels were higher than those in the control group（ P〈0.05）.The MVD（ 68.23 ±15.21）/200 times visual field I in the observation group was significantly lower than the control group（ 75.55±10.61）.The difference was statistically significant（ t = 2.393,P =0.017）.PI was positively correlated with MVD,while RT and TTP were negatively correlated with MVD.Conclusion Ultrasound double contrast can effectively predict and evaluate the effect of neoadjuvant chemotherapy for gastric cancer with liver metastasis.PI can effectively predict the efficacy of neoadjuvant chemotherapy for gastric cancer with liver metastasis,and has high sensitivity.
Chinese Journal of Control of Endemic Disenaces
Ultrasonography double contrast parameter
Neoadjuvant chemotherapy for gastric cancer with liver metastasis