期刊文献+

钇-90微球的剂量计算——钇-90微球放射栓塞系列回顾(四) 预览 被引量:1

Series review of with yttrium- 90 microspheres (Part IV ): dose calculation of yttrium-90 microspheres
在线阅读 下载PDF
分享 导出
摘要 精确的钇-90(^90Y)微球剂量对治疗肝脏恶性肿瘤至关重要,这与临床疗效和不良反应密切相关。剂量的计算主要基于不同的^90Y载体:玻璃微球(TheraSpheres)或树脂微球(SIR-Spheres)。玻璃微球的剂量是以肝脏预期的辐射剂量和微球能够均匀分布于整个肝脏的假设为基础计算的,而树脂微球的剂量是以微球非均匀分布于整个肝脏的假设为基础计算的,这种非均匀分布的程度取决于正常肝脏被肿瘤组织取代的程度。许多其他因素也可能会潜在影响^90Y微球的治疗剂量。本综述将介绍~(90)Y微球剂量的计算方法,以及为了获得最大疗效并尽量避免不良反应发生而需要考虑的各种因素。 Accurate doses of yttrium- 90 (90^Y) microspheres are critical for the treatment of liver malignancies, because it is closely related to the clinical efficacy and adverse reactions. The dose calculation is primarily based on the type of ^90 delivery medium, whether it is glass microsphere (TheraSpheres) or resin microsphere (SIR-Spheres). The dose calculation of glass microspheres is based on the assumption that the expected radiation dose of the liver and the microspheres can be evenly distributed throughout the liver, while the dose calculation of resin microspheres is based on the assumption that the microspheres are not uniformly distributed throughout the liver, and the degree of this inhomogeneous distribution depends on the extent to which the normal liver is replaced by the tumor tissue. Many other factors may also potentially affect the therapeutic dose of ^90Y microspheres. This review will introduce the calculation methods of 90y microsphere dose, and describe the factors that need to be considered in order to achieve maximum efficacy and avoid adverse effects. (J Intervent Radiol, 2018, 27 : 91-95 )
作者 贾中芝 谢双双 郑丽丽 王斯妮 王维平 JIA Zhongzhi, XIE Shuangshuang, ZHENG Lili, WANG Sini, WANG Weiping( Department of Interventional Radiology, Affiliated Chaugzhou Municipal No.2 People's Hospital, Nanjing Medical University, Chaugzhou, Jiangsu Province 213003, China)
出处 《介入放射学杂志》 CSCD 北大核心 2018年第1期91-95,共5页 Journal of Interventional Radiology
基金 江苏省常州市高层次卫生人材培养工程项目(I2016CZBJ009)
关键词 钇-90 剂量 肺分流百分数 肿瘤负荷 yttrium-90 dose lung shunt fraction tumor burden
作者简介 通信作者:王维平E-mail:wang.weiping@mayo.edu
  • 相关文献

同被引文献3

引证文献1

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈