Objective To explore the effect of 7.5% hypertonic saline and mannitol in the treatment of severe hand foot mouth disease complicated with cerebral edema. Methods The clinical data of 30 children with severe hand-foot-mouth disease complicated with cerebral edema admitted in our hospital from April 2012 to April 2017 were restrospectively analyzed, and they were divided into observation group（n=15） and control group（n=15） according to treatmnt methods. The control group was treated with mannitol, while the observation group was treated with 7.5% hypertonic saline and mannitol,the clinical effects between the two group were compared. Results Before treatment, there was no significant difference in the intracranial pressure, mean arterial pressure and central venous pressure between the two groups（P〉0.05）; after treatment, the levels of above indexs in both groups significantly decreased, those in the observation group were lower than the control group（P〈0.05）. The total clinical effective rate of the observation group（93.33%） was significantly higher than that of the control group（73.33%）（P〈0.05）. Conclusion The clinical effect of mannitol combined with 7.5% hypertonic saline is significant in the treatment of children with severe hand-foot-mouth disease complicated with cerebral edema.
CLINCAL RESEARCH AND PRACTICE