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脑内表达的CYP450基因参与内源性物质代谢研究进展 预览

Research progress of CYP450 genes expressed in brain involved in the metabolism of endogenous substances
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摘要 细胞色素P450(cytochrome P450,CYP450)为一类亚铁血红素蛋白超家族,其参与多种内源性及外源性物质(食物成分、药物及污染物等)的代谢与活化。关于CYP450基因,以往的研究主要集中在药物代谢方面,近年来的研究发现CYP450家族成员的作用不仅仅局限于药物代谢,还参与多种疾病的发生及发展进程,包括帕金森病(Parkinson’s disease,PD)、癌症、心肌病及心衰等。目前,关于脑组织内CYP450家族成员参与内源物质代谢的过程及机制尚不十分清楚。本文特总结了脑内表达的CYP450基因对机体内源物质代谢的研究进展,以期为探索脑内表达的CYP450基因的作用提供新的思路。 Cytochrome P450( CYP450) is a superfamily of heme-thiolate proteins,which is involved in the metabolism and activation of various endogenous and exogenous substances,including food,drugs and pollutants. Previous studies of the CYP450 genes mainly focused on their function in drug metabolism. However,in recent years,studies have found that CYP450 are also involved in the development and progression of various diseases,including Parkinson's disease( PD),cancer,cardiomyopathy and heart failure( HF). By far,the process and related mechanisms of CYP450 in the metabolism of endogenous substances in brain tissues has not been clarified yet. In this paper,we summarized the research progress of CYP450 genes involved in the metabolism of endogenous substances,in order to provide a new idea for the exploration of the functions of CYP450 genes expressed in the brain.
作者 杨辛兰 吕丹 张连峰 YANG Xinlan, LV Dan, ZHANG Lianfeng(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative MedicineCenter, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine, NationalHealth and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China)
出处 《中国比较医学杂志》 北大核心 2018年第1期113-117,共5页 Chinese Journal of Comparative Medicine
基金 北京市自然科学基金(编号:5172027) 国家自然科学基金(编号:31301932)
关键词 脑组织 细胞色素P450 内源物质 代谢 brain tissues cytochrome P450 endogenous substances metabolism
作者简介 杨辛兰(1992-),女,硕士研究生,专业:比较医学.E-mail:bsuyxl@sina.com;[通信作者]张连峰,男.E-mail:zhanglf@cnilas.org
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